Synthesis and Angiotensin Converting Enzyme Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. I

スポンサーリンク

概要

• 論文の詳細を見る

• The design and synthesis of new structural types of angiotensin converting enzyme (ACE) inhibitors, (R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acids (7,26,33 and 37) and (S)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acids (8 and 27), are described. A number of compounds in these series showed potent ACE inhibitory activity in vitro and in vivo. The structure-activity relationship is also discussed.

• 社団法人日本薬学会の論文
• 1986-03-25

著者

• 西川 浩平

  日本製薬株式会社研究本部

• 西川 浩平

  Pharamaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries

• 伊藤 克己

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 稲田 義行

  武田薬品工業株式会社研究推進部

• 郡 正城

  Pharmaceutical Research Laboratories, Takeda Chemical Industries, Ltd.,

• 伊藤 克己

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 郡 正城

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 稲田 義行

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 西川 浩平

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 川松 豊

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 杉原 弘貞

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 伊藤 克巳

  武田薬品工業

• 伊藤 克已

  Central Research Division Takeda Chemical Industries Ltd.

• 川松 豊

  干寿製薬株式会社経営戦略室

• 郡 正城

  Pharmaceutical Research Laboratories Takeda Chemical Industries Ltd.

• 稲田 義行

  武田薬品工業株式会社 医療開拓研究本部

• 杉原 弘貞

  Pharamaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries

• 杉原 弘貞

  Central Research Division Takeda Chemical Industries. Ltd.

関連論文

• Synthesis and Platelet-Activating Factor (PAF)-Antagonistic Activities of Trisubstituted Piperazine Derivatives
• Synthesis and Platelet-Activating Factor (PAF)-Antagonistic Activities of 1,4-Disubstituted Piperazine Derivatives
• Thromboxane B2のRadioimmunoassay--生体試料への応用
• 6-Keto-prostaglandin F1αのRadioimmunoassay
• アンジオテンシン II 受容体拮抗薬 : カンデサルタン シレキセチルの創製
• Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of N-[(1S)-1-Carboxy-5-(4-piperidyl)pentyl]-L-alanine Derivatives
• Synthesis and Biological Activities of New 2-Substituted 1,4-Benzoxazine Derivatives
• Synthesis and Biological Activities of New 1,4-Benzothiazine Derivatives
• Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. III
• Synthesis and Angiotensin converting Enzyme Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. II
• Synthesis and Angiotensin Converting Enzyme Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. I
• 高血圧自然発症ラットの高血圧発症機構における腎トロンボキサンA2及びプロスタグランジンの役割
• Structure-Activity Study of Diuretic Azanaphthalene Derivatives
• Structure-Activity Relationships of the Diuretic Activity of Triaza- and Tetraaza-naphthalene Compounds
• 18.Thiamine tetrahydrofurfuyl disulfide側鎖の尿中代謝物(第169回会議研究発表要旨)
• 3.Thiamine propyldisulfide-^S(outer)の尿中代謝物(第168回会議研究発表要旨)
• 1,5-Benzoxathiepin Derivatives. II. Synthesis and Serotonin S_2-Receptor-BIocking Activity of Aminoalkyl-Substituted 3,4-Dihydro-2H-1,5-benzoxathiepin-3-ols and Related Compounds(Medicinal Chemistry,Chemical)
• 1,5-Benzoxathiepin Derivatives. I. Synthesis and Reaction of 1,5-Benzoxathiepin Derivatives(Medicinal Chemistry,Chemical)
• Spirocyclopropane Compounds. II. Synthesis and Biological Activities of Spiro [cyclopropane-1,2'-[2H] indol]-3'(1'H)-ones
• インスリン抵抗性改善薬ピオグリタゾンの創製
• Studies on Antidiabetic Agents. VII. : Synthesis and Hypoglycemic Activity of 4-Oxazoleacetic Acid Derivatives
• Studies on Antidiabetic Agents. II. Synthesis of 5-[4-(1-Methylcyclohexylmethoxy)-benzyl] thiazolidine-2,4-dione (ADD-3878) and Its Derivatives
• Studies on Antidiabetic Agents. I. Synthesis of 5-[4-(2-Methyl-2-phenylpropoxy)-benzyl] thiazolidine-2,4-dione (AL-321) and Related Compounds
• The Synthesis of N, N'-Disubstituted 2,5-Diamino-6-hydroxy-1,2,3,4-tetrahydro-1-naphthalenol Derivatives
• Syntheses and β-Adrenoceptor Activities of 2-Alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols
• The Syntheses and β-Adrenoceptor Activities of N-Substituted 2-Amino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenols
• Optically Active Antifungal Azoles. III. Synthesis and Antifungal Activity of Sulfide and Sulfonamide Derivatives of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H, 1,2,4-triazol-1-yl)-2-butanol
• Optically Active Antifungal Azoles. I. Synthesis and Antifungal Activity of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol and Its Stereoisomers
• 世界に誇れる日本の創薬と将来
• New 1,4-Dihydropyridine Derivatives with Potent and Long-Lasting Hypotensive Effect
• Studies on Antidiabetic Agents. VI. Asymmetric Transformation of (±)-5-[4-(1-Methylcyclohexylmethoxy) benzyl]-2,4-thiazolidinedione (Ciglitazone) with Optically Active 1-Phenylethylamines
• Studies on Antidiabetic Agents. IV. Synthesis and Activity of the Metabolites of 5-[4-(1-Methylcyclohexylmethoxy) benzyl]-2,4-thiazolidinedione (Ciglitazone)
• Antiulcer Activity of 5-Benzylthiazolidine-2,4-dione Derivatives
• Studies on Antidiabetic Agents. III. 5-Arylthiazolidine-2,4-diones as Potent Aldose Reductase Inhibitors
• 1,5-Benzoxathiepin Derivatives. III. Optical Resolution of Methyl (±)-cis-3-Hydroxy-4-[3-(4-phenyl-1-piperazinyl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate Hydrochloride ((±)-CV-5197) with Selective 5-Hydroxytryptamine_2(5-HT_2)-Antagonistic
• Synthesis and β-Adrenergic Blocking Activity of 2-(N-Substituted amino)-1,2,3,4-tetrahydronaphthalen-1-ol Derivatives
• Synthesis of 2-(N-Substituted amino)-6-hydroxy-1,2,3,4-tetrahydronaphthalen-1-ol Derivatives
• Syntheses of 6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol Derivatives
• Studies on the Syntheses of N-Heterocyclic Compounds. XXVI. Syntheses of Pyrido [3,4-d] pyridazine Derivatives. (3)
• Studies on the Syntheses of N-Heterocyclic Compounds. XXV. Syntheses of Pyrido [3,4-d] pyridazine Derivatives. (2)
• Studies on the Syntheses of N-Heterocyclic Compounds. XXIV. Oxidation of Dihydrotetraazanaphthalene Derivatives
• Studies on the Syntheses of N-Heterocyclic Compounds. XXII. The Reaction of Polyazanaphthalene Derivatives with Organometallic Reagents
• Syntheses of 1,2-N-Alkylimino-1,2,3,4-tetrahydronaphthalene Derivatives and Preparation of Ring Closed Analog of Salbutamol as a New β-Adrenoceptor Agent
• カンデサルタン シレキセチル:新世代のアンジオテンシンII受容体拮抗薬の薬理特性と臓器保護作用
• Synthesis and Human Immunodeficiency Virus (HIV)-1 Protease Inhibitory Activity of Tripeptide Analogues Containing a Dioxoethylene Moiety
• 創薬研究の苦しみと喜び
• Spirocyclopropane Compounds. III. Synthesis of Spiro [benzofuran-2 (3H), 1'-cyclopropan]-3-ones for Evaluation as Gastric Antisecretory and Antiulcer Agents
• Chemistry of Salicylic Acid and Anthranilic Acid. I. Reduction of Methyl Salicylate, Methyl Anthranilate and Their Derivatives with Sodium Borohydride
• Chemistry of Salicylic Acid and Anthranilic Acid. II. Formation of 2-Alkyl-3-(2-carboxyphenyl)-4-quinazolone from 2-Alkyl-4-oxo-4H-3,1-benzoxazine by Dimeric Condensation
• Decomposition of Thiamine in Alcohol Solution. II
• Pyrrolo[1,2-α]indole誘導体の合成
• Studies on the Syntheses of N-Heterocyclic Compounds. VII. 2-Aryl-5,8-disubstitutedpyrimido [4,5-d] pyridazine
• Studies on the Syntheses of N-Heterocyclic Compounds. V. 2-Aryl-5,8-dichloropyrimido [4,5-d] pyridazine
• Optically Active Antifungal Azoles. V. Synthesis and Antifungal Activity of Stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols
• Optically Active Antifungal Azoles. IV. Synthesis and Antifungal Activity of (2R, 3R)-3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols
• Optically Active Antifungal Azoles. II. Synthesis and Antifungal Activity of Polysulfide Derivatives of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol
• 含窒素複素環式化合物の合成研究(第12報)Pyrido[3,4-d]pyridazineおよびPyrido[2,3-d]pyridazine誘導体の合成
• Syntheses of conformationally Rigid Catecholamine Derivatives
• 含窒素複素環式化合物の合成研究(第19報)4-Alkyl-5,8-disubstituted Amino-2-phenyl-3,4-dihydropyrimido[4,5-d]pyridazineの合成
• Spirocyclopropane Compounds. VI. : Synthesis of Spiro[benzo[b]-thiophene-2(3H), 1'-cyclopropan]-3-ones
• Spirocyclopropane Compounds. I. Synthesis and Reactivity of Spiro [cyclopropane-1,2'-[2H] indol]-3'(1'H)-ones
• Synthesis and Glutamate-Agonistic Acitivity of (S)-2-Amino-3-(2,5-dihydro-5-oxo-3-isoxazolyl)-propanoic Acid Derivatives
• Stereoselective Syntheses of cis- and trans-2-Alkylamino-1,2,3,4-tetrahydro-1-naphthalenols by Acid-catalyzed Ring Opening of 1,2-N-Alkylimino-1,2,3,4-tetrahydronaphthalenes
• 14 イソプレノイドキノン類の合成
• Synthesis and Biological Activities of 3-Aminomethyl-1,2-dihydronaphthalene Derivatives
• Design and Synthesis of N-[N-[(S)-1-Ethoxycarbonyl-3-phenylprolyl]-L-alanyl]-N-(indan-2-yl)glycine (CV-3317), a New, Potent Angiotensin Converting Enzyme Inhibitor
• Synthesis of 3-Aryl-6-aminocyclohex-2-enol Derivatives
• The Synthesis of 7,8-Dihydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-1-ol
• Sterische Struktur der Giftstoffe aus dem Fruchtfleisch von Ginkgo biloba L.
• An Improved Synthesis of the New Angiotensin Converting Enzyme Inhibitor CV-5975 via a Chemoenzymatic Process(Organic,Chemical)
• Stereoselective Synthesis of cis-and trans-3-Amino-4-chromanols
• 非ペプチド型アンジオテンシンII受容体拮抗薬 : 薬物受容体研究の新動向
• Analysis of 1,4-Dimorpholino-7-phenylpyrido [3,4-d] pyridazine (DS-511) and Its Metabolites in Biological Specimens. III. Fluorodensitometric Method for the Simultaneous Determination of DS-511 and Its Metabolites in Urine and Bile

もっと見る 閉じる

スポンサーリンク