Chemistry of Salicylic Acid and Anthranilic Acid. II. Formation of 2-Alkyl-3-(2-carboxyphenyl)-4-quinazolone from 2-Alkyl-4-oxo-4H-3,1-benzoxazine by Dimeric Condensation
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概要
- 論文の詳細を見る
Treatment of 2-alkyl-4-oxo-4H-3,1-benzoxazines (Ia-d, f, i, l) with ethanol gave 2-alkyl-3-(2-carboxyphenyl)-4-quinazolones (VIIa-d, f, i, l) along with the liberation of ethyl alkanoate. This dimeric condensation may be explained in terms of the contribution of the C=N double bond of Ia-d, f, i, l. It was also revealed that the intermediate of the formation of 4-quinazolone (XVIII) in the reaction of Ia with aniline, was the amidine (XVII), which was produced by the addition of aniline to the C=N double bond of Ia.
- 公益社団法人日本薬学会の論文
- 1979-02-25
著者
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川松 豊
干寿製薬株式会社経営戦略室
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朝川 博之
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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川松 豊
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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俣野 光雄
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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朝川 博之
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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俣野 光雄
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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