Chemistry of Salicylic Acid and Anthranilic Acid. IV. Synthesis of 6-Chloro-5-sulfamoyl-and 6-Chloro-3-sulfamoylanthranilic Acid Derivatives

概要

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Some derivatives of 6-chloro-5-sulfamoyl-and 6-chloro-3-sulfamoylanthranilic acids, which have a chlorine atom and a sulfamoyl group ortho and meta to the carboxy group, respectively, were synthesized and the diuretic activities of the two positional isomers were compared. The presence of a chlorine atom ortho to the carboxy group, which enhanced the hypoglycemic activity of anthranilic acid derivatives, had no effect on the diuretic activity of sulfamoylanthranilic acid derivatives. The diuretic activity of the 6-chloro-3-sulfamoylanthranilic acid derivatives was greater than that of the 6-chloro-5-sulfamoyl ones.
公益社団法人日本薬学会の論文
1979-06-25