Decomposition of Thiamine in Alcohol Solution. II
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概要
- 論文の詳細を見る
Thiamine mononitrate (Ib) was easily decomposed in methanol solution to produce crystalline compound (X') and 5-(2-hydroxyethyl)-4-methylthiazole (III). The structure of this compound (X') was presumed to be pentamethi (1,4-dihydro-4-imino-2-methyl)-pyrimidinylen-1,5-amer nitrate (IIc) from spectral and chemical data, and this was confirmed by the synthesis of 9-amino-2,7,10-trimethyl-5H-dipyrimido [1,6-α : 4', 5'-d] pyrimidine derived from IIc. Compound (X), which was produced by the decomposition of thiamine monochloride (Ia) in methanol, is the hydrochloride of a base in IIc. IIc in aqueous solution reacted with acidic sodium sulfite to give 4-amino-2-methylpyrimidinyl-5-methanesulfonic acid (IX), and with III to give Ib.
- 公益社団法人日本薬学会の論文
- 1974-09-25
著者
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平野 弘
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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島原 登
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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川松 豊
干寿製薬株式会社経営戦略室
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朝川 博之
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
平野 弘
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
-
川松 豊
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
朝川 博之
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
-
島原 登
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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