Studies on the Syntheses of N-Heterocyclic Compounds. V. 2-Aryl-5,8-dichloropyrimido [4,5-d] pyridazine

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概要

• 論文の詳細を見る

• 2-Substituted-5,6,7,8-tetrahydropyrimido [4,5-d] pyridazine-5,8-diones (6) having a variety of substituents at 2-position were synthesized. Chlorination reaction of 6 were carried out, and it was found that only the compound which have aryl substituent at 2-position could be converted to 2-aryl-5,8-dichloropyrimido [4,5-d] pyridazine (14), while other derivatives gave no corresponding dichlorides (14). 2,4-Diphenyl-5,6,7,8-tetra-hydropyrimido [4,5-d] pyridazine-5,8-dione (9) was not obtained because of its structural unstability caused by steric interference of phenyl group at 4-position.

• 公益社団法人日本薬学会の論文
• 1972-07-25

著者

• 万木 庄次郎

  武田薬品中研

• 川松 豊

  干寿製薬株式会社経営戦略室

• 冨本 光美

  京大(医)衛生学

• 杉原 弘貞

  Chemistry Research Laboratories, Takeda Chemical Industries, Ltd.,

• 杉原 弘貞

  Central Research Division Takeda Chemical Industries. Ltd.

• 川松 豊

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 万木 庄次郎

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 稗田 勝

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 伏見 富吉

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 冨本 光美

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 稗田 勝

  武田薬品工業株式会社, 研究開発本部, 化学研究所

• 稗田 勝

  武田薬品工業株式会社 研究開発本部 化学研究所

• 伏見 富吉

  武田薬品工業株式会社 中央研究所 化学研究所

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