Spirocyclopropane Compounds. VI. : Synthesis of Spiro[benzo[b]-thiophene-2(3H), 1'-cyclopropan]-3-ones

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概要

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• Spiro[benzo[b]thiophene-2(3H), 1'-cyclopropan]-3-ones (IIIc-1-IIIc-11) and their aza analogs, such as spiro[cyclopropane-1,2'(3'H)-thieno[3,2-c]pyridin]-3'-one (IIIc-12) as well as spiro[cyclopropane-1,2'(3'H)-thieno[2,3-b]pyridin]-3'-one (IIIc-13), were synthesized from thiosalicylic acids and from 4- and 2-mercaptonicotinic acids, respectiely, in three steps. Decarboxylation of 4', 5'-dihydrospiro[benzo[b]thiophene-2(3H), 3'(2'H)-furan]-2', 3-diones (IIc) gave 2,3-dihydrobenzo[b]thieno[3,2-b]furans (IVc) along with the desired spirocyclopropane compounds (IIIc).The ratios of IIIc to IVc were greatly influenced by the substituents on the benzene ring.

• 公益社団法人日本薬学会の論文
• 1986-05-25

著者

• 杉原 弘貞

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 川田 満

  Central Research Division, Takeda Chemical Industries, Ltd.

• 今田 伊助

  Central Research Division, Takeda Chemical Industries, Ltd.

• 杉原 弘貞

  Pharamaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries

• 杉原 弘貞

  Central Research Division Takeda Chemical Industries. Ltd.

• 今田 伊助

  Central Reseach Division Takeda Chemical Industries Ltd.

• 川田 満

  Central Research Division Takeda Chemical Industries Ltd.

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