含窒素複素環式化合物の合成研究(第12報)Pyrido[3,4-d]pyridazineおよびPyrido[2,3-d]pyridazine誘導体の合成
スポンサーリンク
概要
- 論文の詳細を見る
1,2,3,4-Tetrahydro-7-phenylpyrido[3,4-d]pyridazine-1,4-dione (18) and 2-phenyl-5,6,7,8- tetrahydropyrido[2,3-d]pyridazine-5,8-dione (22) were converted to the corresponding dichlorides, which were allowed to react with amines to give 1,4-bis(substitutedamino)-7-phenylpyrido[3,4-d]pyridazines (9) and 2-phenyl-5,8-bis(substituted amino)pyrido[2,3-d]-pyridazines (10). Among these compounds, 1,4-dimorpholino-7-phenylpyrido[3,4-d]pyridazine (5a) and 2-phenyl-5,8-bis(isopropylamino)pyrido[2,3-d]pyridazine (6c) showed a strong diuretic activity.
- 公益社団法人日本薬学会の論文
- 1972-11-25
著者
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杉原 弘貞
武田薬品工業(株)開拓第一研究所
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万木 庄次郎
武田薬工研究開発本部化学研究所
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杉原 弘貞
Central Research Division Takeda Chemical Industries. Ltd.
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万木 庄次郎
武田薬品工業株式会社 研究開発本部 化学研究所
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伏見 富吉
武田薬品工業株式会社, 研究開発本部, 化学研究所
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稗田 勝
武田薬品工業株式会社, 研究開発本部, 化学研究所
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稗田 勝
武田薬品工業株式会社 研究開発本部 化学研究所
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伏見 富吉
武田薬品工業株式会社 中央研究所 化学研究所
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