Spirocyclopropane Compounds. V. One-Step Synthesis of 5-Acetylspiro [benzofuran-2 (3H), 1'-cyclopropan]-3-one

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概要

• 論文の詳細を見る

• 5-Acetylspiro [benzofuran-2 (3H), 1'-cyclopropan]-3-one (3a, AG-629), previously found to be the most potent antiulcer compound in a series of spirocyclopropanes, was obtained by onestep synthesis starting from methyl 5-acetyl-2-[(tetrahydro-2-oxo-3-furanyl) oxy] benzoate (1a). In this reaction, 5,10'-(diacetyl-5', 6'-dihydrospiro [benzofuran-2 (3H), 4'(3'H)-[2H] oxocino [3,2-b]-benzofuran]-3-one (5a), which has a new ring system, and 1H, 3H-8-acetyl-4,5-dihydronaphtho [1,2-c : 4,3-b'] difuran-1-one (6) were isolated as by-products. A possible reaction mechanism is presented.

• 社団法人日本薬学会の論文
• 1984-09-25

著者

• 野口 俊作

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division Takeda Chemical Industries Ltd.

• 渡辺 正純

  Central Research Division, Takeda Chemical Industries, Ltd.

• 川田 満

  Central Research Division, Takeda Chemical Industries, Ltd.

• 高本 正幸

  Central Research Division, Takeda Chemical Industries, Ltd.

• 今田 伊助

  Central Research Division, Takeda Chemical Industries, Ltd.

• 今田 伊助

  Central Reseach Division Takeda Chemical Industries Ltd.

• 川田 満

  Central Research Division Takeda Chemical Industries Ltd.

• 渡辺 正純

  Central Reseach Division Takeda Chemical Industries Ltd.

• 高本 正幸

  Faculty of Pharmaceutical Sciences, Tokyo University

• 高本 正幸

  Faculty Of Pharmaceutical Sciences Tokyo University

• 高本 正幸

  Central Research Division Takeda Chemical Industries Ltd.

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