Spirocyclopropane Compounds. I. Synthesis and Reactivity of Spiro [cyclopropane-1,2'-[2H] indol]-3'(1'H)-ones
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概要
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A spirocompound, 1'-acetylspiro [cyclopropane-1,2'-[2H] indol]-3'(1'H)-one (III-1), was synthesized from anthranilic acid in three steps, which involve the condensation of anthranilic acid with α-bromo-γ-butyrolactone, followed by spiroannelation with acetic anhydride and triethylamine, and subsequent decarboxylation in the presence of sodium chloride to afford III-1 in good yield. Various derivatives (III-2-III-9) were similarly prepared. Some compounds of this series showed an intense fluorescence in solution. The reactivities of III-1 to electrophiles and nucleophiles, as well as its reaction with reducing agents, were investigated.
- 公益社団法人日本薬学会の論文
- 1981-07-25
著者
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川野 泰彦
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries
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川野 泰彦
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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川田 満
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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杉原 弘貞
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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杉原 弘貞
Pharamaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries
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今田 伊助
Central Reseach Division Takeda Chemical Industries Ltd.
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川田 満
Central Research Division Takeda Chemical Industries Ltd.
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武居 三郎
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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今田 伊助
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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武居 三郎
Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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