Synthesis and Antibacterial Activity of 3-Acylamino-3-methoxy-2-azetidinone-1-sulfonic Acid Derivatives

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概要

• 論文の詳細を見る

• As a key intermediate for the synthesis of sulfazecin derivatives, 3-amino-3-methoxy-2-azetidinone (24 or 26) was synthesized from penicillins, and various new compounds, including sulfazecin, were synthesized by acylation and sulfonation of 24 or 26. Some of these compounds (33,36) showed higher antibacterial activity than the corresponding 3-demethoxy derivatives against a β-lactamase-producing strain of Escherichia coli.

• 公益社団法人日本薬学会の論文
• 1983-07-25

著者

• 松尾 泰介

  Central Research Division, Takeda Chemical Industries, Ltd.

• 落合 道彦

  Central Research Division, Takeda Chemical Industries, Ltd.

• 川野 泰彦

  Central Research Division, Takeda Chemical Industries, Ltd.

• 川野 泰彦

  Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries

• 川野 泰彦

  Central Research Division Takeda Chemical Industries Ltd.

• 菅原 徹

  Molecular Chemistry Laboratory, Takeda Chemical Industries Ltd.,

• 菅原 徹

  Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.

• 菅原 徹

  Central Research Division, Takeda Chemical Industries, Ltd.

• 桝屋 浩大

  Central Research Division, Takeda Chemical Industries, Ltd

• 落合 道彦

  Central Research Division Takeda Chemical Industries Ltd.

• 野口 典良

  Central Research Division, Takeda Chemical Ind., Ltd.

• 桝屋 浩大

  Central Research Division Takeda Chemical Ind. Ltd.

• 松尾 泰介

  Central Research Division Takeda Chemical Industries Ltd.

• 野口 典良

  Central Research Division Takeda Chemical Ind. Ltd.

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