Studies on the Diels-Alder Reaction of 4-Carboxymethyl-5-ethoxyoxazole
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概要
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The Diels-Alder reaction of 4-carboxymethyl-5-ethoxyoxazole (I) was investigated. First, the mechanism and the stereochemistry of the adducts in the course of the Diels-Alder reaction were discussed. Second, the reaction of I with asymmetrical dienophiles gave the substance that an electron attracting group was preferentially introduced at γ-position of pyridine nucleus. Finally, the reaction of I with maleic anhydride, fumaric acid, maleic acid and methacrylic acid afforded the decarboxylated compounds. The mechanism of these reaction was discussed.
- 公益社団法人日本薬学会の論文
- 1972-04-25
著者
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三木 卓一
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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松尾 泰介
Central Research Division, Takeda Chemical Industries, Ltd.
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三木 卓一
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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三木 卓一
Research Laboratories, Takeda Chemical Industries, Ltd.
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三木 卓一
武田薬品工業株式会社研究開発本部
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松尾 泰介
Research & Development Division, Takeda Chemical Industries, Ltd.
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Miki Takuichi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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