Synthesis and Antibacterial Activity of 3-Acylamino-2-azetidinone-1-sulfonic Acid Derivatives

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概要

• 論文の詳細を見る

• Sulfazecin (1) is a monocyclic β-lactam antibiotic isolated from strain G-6302,Pseudomonas acidophila. As a key intermediate for the synthesis of sulfazecin derivatives, 3-amino-2-azetidinone (16) was synthesized from penicillins, and various new compounds were synthesized by acylation and sulfonation of 16. Some of these new compounds showed potent antibacterial activity.

• 公益社団法人日本薬学会の論文
• 1983-06-25

著者

• 松尾 泰介

  Central Research Division, Takeda Chemical Industries, Ltd.

• 落合 道彦

  Central Research Division, Takeda Chemical Industries, Ltd.

• 川野 泰彦

  Central Research Division, Takeda Chemical Industries, Ltd.

• 川野 泰彦

  Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries

• 川野 泰彦

  Central Research Division Takeda Chemical Industries Ltd.

• 菅原 徹

  Molecular Chemistry Laboratory, Takeda Chemical Industries Ltd.,

• 菅原 徹

  Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.

• 菅原 徹

  Central Research Division, Takeda Chemical Industries, Ltd.

• 桝屋 浩大

  Central Research Division, Takeda Chemical Industries, Ltd

• 落合 道彦

  Central Research Division Takeda Chemical Industries Ltd.

• 野口 典良

  Central Research Division, Takeda Chemical Ind., Ltd.

• 桝屋 浩大

  Central Research Division Takeda Chemical Ind. Ltd.

• 松尾 泰介

  Central Research Division Takeda Chemical Industries Ltd.

• 野口 典良

  Central Research Division Takeda Chemical Ind. Ltd.

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