Synthetic Studies on Condensed-Azole Derivatives. III. Synthesis and Anti-asthmatic Activities of C-Substituted Alkyl Side Chain Derivatives of ω-Sulfamoylalkylthioimidazo[1,2-b]pyridazines and Related Compounds
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概要
- 論文の詳細を見る
A series of novel alkylthioimidazo[1,2-b]pyridazines was synthesized and evaluated for ability to inhibit platelet activating factor (PAF)-induced bronchoconstriction in guinea pigs. Among them, 3-(imidazo[1,2-b]pyridazin-6-yl)thio-2,2-dimethylpropanesulfonamide (15) showed the most potent inhibitory effect. The structure-activity relationships in this series of compounds, in particular, the effects of conversiton of the imidazopyridazine ring into other heterocyclic rings, introduction of a substituent group at the 2 or 3 position of the imidazopyridazine ring and introduction of a substituent group into the alkyl side chain, are also discussed.
- 社団法人日本薬学会の論文
- 1995-09-15
著者
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桑原 雅明
Pharmaceutical Research Division, Pharmaceutical Research Laboratories III Takeda Chemical Industrie
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三宅 昭夫
Pharmaceutical Research Division, Pharmaceutical Research Laboratories III Takeda Chemical Industrie
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山本 弘昭
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industires
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川野 泰彦
Pharmaceutical Research Division, Pharmaceutical Research Laboratories III, Takeda Chemical Industir
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島津 浩
Pharmaceutical Research Division, Pharmaceutical Research Laboratories III, Takeda Chemical Industir
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蘆田 康子
Pharmaceutical Research Laboratories II, Takeda Chemical Industries, Ltd.,
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蘆田 康子
武田薬品・創薬研究本部
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川野 泰彦
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries
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三宅 昭夫
武田薬品・創薬研究本部
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島津 浩
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industires
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桑原 雅明
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries
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Miyake Akio
Pharmaceutical Research Division Pharmaceutical Research Laboratories Ii Research Promotion Takeda C
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Kuwahara Masaaki
Pharmaceutical Research Division Pharmaceutical Research Laboratories Ii Research Promotion Takeda C
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蘆田 康子
Pharmaceutical Research Laboratories Ii Takeda Chemical Industries Ltd.
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Yamamoto Hiroaki
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries
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Kawano Y
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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