Synthesis of the Epimer of Pericosine B from (-)-Quinic Acid
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概要
- 論文の詳細を見る
Synthesis of the epimer of pericosine B from (-)-quinic acid was achieved. This synthesis involves some regioselective and stereoselective processes. The desired product showed lower cytotoxic activity in comparison with natural pericosine B against the P388 leukemia cell line. The result implies that the stereocenter of C-6 in natural pericosine B plays an important role in this activity.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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山本 弘昭
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industires
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USAMI Yoshihide
Osaka University of Pharmaceutical Sciences
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NUMATA Atsushi
Osaka University of Pharmaceutical Sciences
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Tanabe M
Osaka University Of Pharmaceutical Sciences
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Yamamoto H
Osaka University Of Pharmaceutical Sciences
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Numata Atsushi
Osaka College Of Pharmacy
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HATSUNO Chikage
Osaka University of Pharmaceutical Sciences
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YAMAMOTO Hiroe
Osaka University of Pharmaceutical Sciences
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TANABE Manabu
Osaka University of Pharmaceutical Sciences
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Tanabe M
Showa College Of Pharmaceutical Sciences
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Usami Yoshihide
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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