Inhibitory Activities of 2-Pyridinecarboxylic Acid Analogs on Phytogrowth and Enzymes

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概要

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• Five 2-pyridinecarboxylic acid-related compounds (1,2 and 5-7) showed germination inhibition against the seed of Brassica campestris L. subsp. rapa HOOK fil et ANDERS at a concentration of 5.0×10^<-4>M. These compounds also demonstrated inhibitory activity on the growth of the root of this plant at a concentration of 3.0×0^<-4>M; among these compounds, 2-pyridylacetic acid (5) showed the strongest inhibitory activity, and the effect was slightly stronger than that of sodium 2,4-dichlorophenoxyacetate (2,4-D) used as a positive control. The amounts of chlorophyll in the cotyledons of this plant treated with these active compounds was lower than that of the control group. Four compounds (1 and 5-7) with germination inhibition also showed inhibitory activities against α-amylase and carboxypeptidase A, and 5 was the strongest inhibitor toward both enzymes.

• 公益社団法人日本薬学会の論文
• 1999-11-15

著者

• NUMATA Atsushi

  Graduate School of Pharmaceutical Sciences, Tohoku University

• TSUJIBO Hiroshi

  Osaka University of Pharmaceutical Sciences

• INAMORI Yoshihiko

  Osaka University of Pharmaceutical Sciences

• YAMADA Takeshi

  Osaka University of Pharmaceutical Sciences

• NUMATA Atsushi

  Osaka University of Pharmaceutical Sciences

• SAKAGAMI YOSHIKAZU

  Osaka Prefectural Institute of Public Health

• SAKAGAMI YOSHIKAZU

  Kinki University, Faculty of Agriculture

• TSUJIBO Hiroshi

  Department of Microbiology, Osaka University of Pharmaceutical Sciences

• Sakagami Yoshikazu

  Kinki University Faculty Of Agriculture

• Sakagami Y

  Osaka Prefectural Institute Of Public Health

• Yamanaka Hiromi

  Osaka University Of Pharmaceutical Sciences

• Numata A

  Graduate School Of Pharmaceutical Sciences Tohoku University

• Numata A

  Osaka University Of Pharmaceutical Sciences

• Numata Atsushi

  Osaka College Of Pharmacy

• HIRAI Yuka

  Osaka University of Pharmaceutical Sciences

• Yamada Takao

  Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University

• Tsujibo H

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Yamada T

  Laboratory Of Applied Bioorganic Chemistry Division Of Life Science Graduate School Of Agricultural

• Yamaguchi H

  Research And Development Center Nagase & Co. Ltd.

• Numata Atsushi

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• Inamori Yoshihiko

  Osaka College Of Pharmacy

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