Polysaccharide of Astragali Radix Enhances IgM Antibody Production in Aged Mice
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概要
- 論文の詳細を見る
The effect of Astragali Radix (AR) on IgM antibody production in mice of various ages (10 weeks, 36 weeks and 60 weeks) was examined. The antibody production levels in the 36- and 60-week-old mice were significantly decreased to about 70 and 60% of that in the 10-week-old mice. The enhancement effect of a crude polysaccharide AR fraction on the antibody production was nil in the 10-week-old mice, but significant enhancement effects were observed in the 36- and 60-week-old, mice, compared to the age-matched control.Two polysaccharides active in the enhancement of the IgM antibody production in the aged mice were isolated from the high molecular weight fraction of AR by cetavlon precipitation, ion-exchange and gel permeation chromatography. The molecular masses of these polysaccharides were calculated by HPLC in salt solution. Only one major peak was observed for each, and their molecular masses were estimated to be 1.2×10^4 and 2.2×10^4.The major components of these polysaccharides were neutral carbohydrates (89.3 and 95.5%), followed by uronic acid and protein / glucose was the predominant sugar component.
- 公益社団法人日本薬学会の論文
- 1997-11-15
著者
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Mimura Mayumi
Osaka Prefectural Institute Of Public Health
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Mimura Mayumi
大阪府立公衆衛生研究所
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Takagi Yasuhiro
Osaka City University School of Medicine, Department of Cardiology
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KAJIMURA Keiji
Osaka Prefectural Institute of Public Health
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Sawabe Yoshiyuki
Osaka Prefectural Institute of Public Health
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Kajimura Keiji
大阪府立公衆衛生研究所
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Takagi Y
Santen Pharmaceutical Co. Ltd. Ikoma Jpn
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SAKAGAMI YOSHIKAZU
Osaka Prefectural Institute of Public Health
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Yokoyama H
Osaka Pharmaceutical Association
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YOKOYAMA HIROSHI
Osaka Pharmaceutical Association
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YONEDA Kaisuke
Faculty of Pharmaceutical Sciences, Osaka University
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MIYANO Keiichi
Osaka Prefectural Institute of Public Health
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Yoneda K
Faculty Of Pharmaceutical Sciences Osaka University
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Takagi Yasuhiro
Osaka Prefectural Institute Of Public Health
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Sawabe Y
Osaka Prefectural Inst. Public Health Osaka Jpn
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Yoneda Kaisuke
Faculty Of Pharmaceutical Sciences Osaka University
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