Effects of Preparations of Chinese Medicinal Prescriptions on Digestive Enzymes in Vitro and in Vivo
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概要
- 論文の詳細を見る
The effects of preparations of Chinese medicinal prescriptions on the activities of digestive enzymes were investigated. The starch dextrinizing activity of pancreatin was inhibited by Keishi-bukuryo-gan, Sho-seiryu-to, Hachimi-jio-gan, Unsei-in and Keishi-ka-shakuyaku-to to below 40% of the control activity. Hachimi-jio-gan and Sho-seiryu-to, in particular, lowered the activity to 4% and 24% of the control activity, respectively. The protein digestive activity of pancreatin was lowered by Keishi-bukuryo-gan, Oren-gedoku-to, Ryutan-shakan-to, Tokaku-joki-to, Yokuinin-to and Hange-shashin-to, to 56 to 70% of the control activity.To investigate the effects of the preparations of Chinese medicinal prescriptions on digestive enzymes in vivo, 600 mg (185 kBq) of ^<125>I-egg white albumin were administered orally to rats 30 min before the administration of 100 mg of Tokaku-joki-to or Oren-gedoku-to. The radioactivity which transferred to the blood was less in the animals pre-fed these prescriptions than in the control animals, indicating that the digestion of egg white albumin was delayed in the presence of the prescriptions.
- 公益社団法人日本薬学会の論文
- 1998-02-15
著者
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KAJIMURA Keiji
Osaka Prefectural Institute of Public Health
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Yamasaki K
Faculty Of Pharmaceutical Sciences Teikyo Heisei University
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Yamasaki Katsuhiro
Osaka Prefectural Institute of Public Health
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Kajimura Keiji
大阪府立公衆衛生研究所
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NAKANO Masami
Osaka Prefectural Institute of Public Health
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Yokoyama H
Osaka Pharmaceutical Association
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Nishio M
Tanabe Seiyaku Co. Ltd. Saitama Jpn
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Nishio Maki
Department Of Bioscience And Informatics Faculty Of Science And Technology Keio University
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YOKOYAMA HIROSHI
Osaka Pharmaceutical Association
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YONEDA Kaisuke
Faculty of Pharmaceutical Sciences, Osaka University
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UMEZAWA Chisae
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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Yoneda K
Faculty Of Pharmaceutical Sciences Osaka University
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Umezawa Chisae
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Umezawa Chisae
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Nakano M
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd
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Yoneda Kaisuke
Faculty Of Pharmaceutical Sciences Osaka University
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