Protective Effect of Astragali Radix by Intraperitoneal Injection against Japanese Encephalitis Virus Infection in Mice
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概要
- 論文の詳細を見る
We examined the protective effect of Astragali Radix extracts (AE) by intraperitoneal injection against Japanese encephalitis virus (JEV) infection in mice. A protective effect was observed by all four samples of AE used. However, the degree of effectiveness for each AE was different. The observed survival rates of the groups injected with sample A (from Shanhsi, Japanese name Sansei-syo) and sample D (from Hokkaido) extracts were higher than 80% at 21 d after JEV inoculation. The groups injected with sample B (from Hopei, Japanese name Kahoku-syo) and sample C (from Hsiahsi, Japanese name Sensei-syo) extracts had a 60% survival rate. The increase in hemagglutination inhibition antibody titer was negligible in mice that survived 21 d after JEV inoculation. The antiviral effect of AE was examined by plaque assay in vitro, but no antiviral effect was shown. In mice injected with AE, the peritoneal exudate cell (PEC) numbers increased significantly, compared to the control. In these PEC, active oxygen production was also high. Also the group as a whole displayed a high survival rate against JEV infection, these were so strong.From these results, we propose that the protective effect of AE is dependent on a non-specific mechanism during the early stage of infection, before it shifts to antibody production, and that PEC plays an important role.
- 公益社団法人日本薬学会の論文
- 1996-06-15
著者
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Takagi Yasuhiro
Osaka City University School of Medicine, Department of Cardiology
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KAJIMURA Keiji
Osaka Prefectural Institute of Public Health
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Yamasaki Katsuhiro
Osaka Prefectural Institute of Public Health
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Kajimura Keiji
大阪府立公衆衛生研究所
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Takagi Y
Santen Pharmaceutical Co. Ltd. Ikoma Jpn
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SAKAGAMI YOSHIKAZU
Osaka Prefectural Institute of Public Health
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Yokoyama H
Osaka Pharmaceutical Association
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YOKOYAMA HIROSHI
Osaka Pharmaceutical Association
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YONEDA Kaisuke
Faculty of Pharmaceutical Sciences, Osaka University
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UEBA Noboru
Osaka Prefectural Institute of Public Health
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Ueba N
Osaka Prefectural Institute Of Public Health
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Yoneda K
Faculty Of Pharmaceutical Sciences Osaka University
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Takagi Yasuhiro
Osaka Prefectural Institute Of Public Health
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Yoneda Kaisuke
Faculty Of Pharmaceutical Sciences Osaka University
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