Anti-HIV-1 Activity of Herbs in Labiatae

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概要

• 論文の詳細を見る

• The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro. Forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against HIV-1 induced cytopathogenicity in MT-4 cells. In particular, the aqueous extracts of Melissa officinalis, a family of Mentha×piperita "grapefruit mint", Mentha×piperita var. crispa, Ocimum basilicum cv "cinnamon", Perilla frutescens var. crispa f.viridis, Prunella vulgaris subsp. asiatica and Satureja montana showed potent anti-HIV-1 activity (with an ED of 16μg/ml). The active components in the extract samples were found to be water-solubel polar substances, not nonpolar compounds such as essential oils. In addition, these aqueous extracts inhibited giant cell formation in co-culture of Molt-4 cels with and without HIV-1 infection and showed inhibitory activity against HIV-1 reverse transcriptase.

• 社団法人日本薬学会の論文
• 1998-08-15

著者

• 山崎 勝也

  大阪市立大学医学部生体情報解析学講座

• NAKANISHI Tsutomu

  Faculty of Pharmaceutical Sciences,Setsunan University

• MURATA Hiroko

  Faculty of Pharmaceutical Sciences,Setsunan University

• Murata Hiroko

  摂南大学 薬

• Yamasaki K

  Faculty Of Pharmaceutical Sciences Teikyo Heisei University

• Yamasaki Katsuhiro

  Osaka Prefectural Institute of Public Health

• Murata Hiroko

  Faculty Of Pharmaceutical Sciences Setsunan University

• Otake Toru

  Osaka Prefectural Institute Of Public Health

• Yamasaki K

  Osaka Prefectural Institute Of Public Health

• KAWAHATA Takuya

  Osaka Prefectural Institute of Public Health

• Murata Hiroko

  Faculty Of Human Life Science Osaka City University

• NAKANO Masami

  Osaka Prefectural Institute of Public Health

• MORI Haruyo

  Osaka Prefectural Institute of Public Health

• UEDA Noboru

  Osaka Prefectural Institute of Public Health

• OISHI Isao

  Osaka Prefectural Institute of Public Health

• INAMI Rie

  Osaka University of Pharmaceutical Sciences

• YAMANE Megumi

  Osaka University of Pharmaceutical Sciences

• NAKAMURA Miki

  Osaka University of Pharmaceutical Sciences

• Yamasaki K

  Division Of Medicinal Chemistry Graduate School Of Biomedical Sciences Hiroshima University

• UEBA Noboru

  Osaka Prefectural Institute of Public Health

• Ohnuki T

  Sankyo Co. Ltd. Tokyo Jpn

• Otake Toru

  Otemae College Of Nutrition

• Oishi Isao

  Division Of Virology Department Of Infectious Diseases Osaka Prefectural Institute Of Public Health

• Ueba N

  Osaka Prefectural Institute Of Public Health

• Nakamura Miki

  Osaka University

• Murata H

  Okayama Univ. Okayama Jpn

• Kawahata T

  Division Of Virology Department Of Infectious Diseases Osaka Prefectural Institute Of Public Health

• Nakano M

  Discovery Research Laboratory Tanabe Seiyaku Co. Ltd

• Murata Hiroko

  Division Of Virology Department Of Infectious Diseases Osaka Prefectural Institute Of Public Health

• Nakano Masami

  Faculty Of Pharmaceutical Sciences Setsunan University

• Nakanishi Tsutomu

  Faculty Of Pharmaceutical Sciences Setsunan University

• Nakanishi Tsutomu

  Faculty Of Engineering Miyazaki University

• Okuda Toru

  Otemae College of Nutrition

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