Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells by a Coptidis Rhizoma Extract and Protoberberine Alkaloids(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
A methanol extract of Coptidis Rhizoma effectively enhanced the outgrowth of neurite in PC12 cells induced by nerve growth factor (NGF). Following solvent partition and preparative HPLC, berberine was isolated as the major active compound. Berberine enhanced the proportion of neurite-bearing cells in a dose-dependent manner without cytotoxicity. Its structural relatives, palmatine and coptisine, showed a slightly weaker NGF-enhancing effect than berberine. These three alkaloids inhibited acetylcholinesterase activity at a level comparable to that of physostigmine, but this inhibition was not responsible for the potentiation of NGF-induced neurite outgrowth. It is demonstrated for the first time that protoberberine alkaloids potentiated the NGF-induced differentiation of neural cells.
- 社団法人日本農芸化学会の論文
- 2002-11-23
著者
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Tatemoto Hideki
Fac. Of Agriculture Univ. Of The Ryukyus
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NAKANISHI Tsutomu
Faculty of Pharmaceutical Sciences,Setsunan University
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INADA Akira
Faculty of Pharmaceutical Sciences,Setsunan University
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Tatemoto Hideki
School Of Bioresources Hiroshima Prefectural University
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SHIGETA Koji
School of Bioresources, Hiroshima Prefectural University
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OOTAKI Keisuke
School of Bioresources, Hiroshima Prefectural University
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MUTO Norio
School of Bioresources, Hiroshima Prefectural University
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Muto Norio
Fac. Of Life And Environmental Sci. Prefectural Univ. Of Hiroshima
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Shigeta Koji
School Of Bioresources Hiroshima Prefectural University
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Ootaki Keisuke
School Of Bioresources Hiroshima Prefectural University
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Muto N
Okayama Univ. Okayama
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Iwashima Akio
Kyoto Prefectural University of Medicine
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Inada A
Fac. Of Pharmaceutical Sciences Setsunan Univ.
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Inada Akira
Faculty Of Pharmaceutical Sciences Setsunan University
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Nakanishi Tsutomu
Fac. Of Pharmaceutical Sciences Setsunan Univ.
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Muto N
Graduate School Of Comprehensive Scientific Research Program In Biological System Sciences Prefectur
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Nakanishi T
Fac. Of Pharmaceutical Sciences Setsunan Univ.
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Nakanishi Tsutomu
Faculty Of Pharmaceutical Sciences Setsunan University
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Nakanishi Tsutomu
Faculty Of Engineering Miyazaki University
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