ALTERATION IN GASTRIC MUCOSAL ACID PROTEASE ACTIVITY INDUCED BY NECROTIZING AGENTS AND PREVENTION BY PROSTAGLANDIN E_2
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概要
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Tissue levels of two gastric mucosal acid proteases, pepsinogen and cathepsin D-like acid proteinase, were determined in rat gastric mucosa damaged by various necrotizing agents and the protective effects of prostaglandins against these biological alterations were investigated. Gastric mucosal damage by each necrotizing agent used was associated with a marked decrease in tissue level of cathepsin D-like acid proteinase. Particularly, ethanol ingestion caused its significant reduction parallel to the production of gastric lesions in a time-dependent manner. On the other hand, mucosal pepsinogen level increased markedly only in ethanol-damaged gastric mucosa, indicating that this change was mediated by a different mechanism from that for cathepsin D-like enzyme. In rats pretreated with prostaglandin E_2 and prostaglandin inducers before ethanol administration, these biological alterations of two enzymes were effectively prevented as were gastric lesions. However, ethanol ingestion caused these changes to occur to the same degree in both the necrotic and non-necrotic areas of glandular mucosa. It was considered that cathepsin D-like acid proteinase was released from damaged gastric mucosa through a direct action on cellular membrane different from vasoconstrictor and platelet aggregating actions mediated by arachidonic acid metabolites.
- 社団法人日本薬学会の論文
著者
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Muto Norio
Faculty Of Life And Environmental Sciences Prefectural University Of Hiroshima
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TANI Satoru
Faculty of Pharmaceutical Sciences Josai University
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Tani Satoru
Faculty Of Phamaceutical Sciences Josai University:life Science Research Center Josai University
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YAMAMOTO MAKOTO
Faculty of Pharmaceutical Sciences, Josai University
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Muto Norio
Faculty Of Life And Environmental Science Prefectural University Of Hiroshima
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Muto Norio
Faculty Of Pharmaceutical Sciences Josai University
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Muto N
Graduate School Of Comprehensive Scientific Research Program In Biological System Sciences Prefectur
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Yamamoto M
Hokkaido Univ. Sapporo Jpn
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Yamamoto Makoto
Faculty Of Pharmaceutical Sciences Josai University
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