Trifluoromethyl Ketone-Based Inhibitors of Apoptosis in Cerebellar Granule Neurons
スポンサーリンク
概要
- 論文の詳細を見る
A variety of aromatic trifluoromethyl ketone derivatives has been studied as inhibitors of apoptosis in cerebellar granule neurons (CGNs). Among them, α-trifluoromethyl diketone (2) and benzyl trifluoromethyl ketone (11) were found to be apoptosis inhibitors which can prevent a neurodegenerative disease. Compounds 2 and 11 showed neuroprotection effect on low K^+-induced apoptosis in CGNs. Furthermore, these compounds effectively suppressed DNA fragmentation accompanied with apoptosis. The neuroprotection mode of 2 and 11 was not related to inhibition of caspase-3.
- 社団法人日本薬学会の論文
- 2001-11-01
著者
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Uematsu Toshihiko
Department of Pharmacology, Gifu University School of Medicine
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Niwa M
Department Of Pharmacology Gifu University School Of Medicine
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Niwa Masayuki
Departments Of Pharmacology Gifu University School Of Medicine
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TANI Satoru
Faculty of Pharmaceutical Sciences Josai University
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Tani Satoru
Faculty Of Phamaceutical Sciences Josai University:life Science Research Center Josai University
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SUNAGA Katsuyoshi
Faculty of Phamaceutical Sciences, Josai University
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KAWASE Masami
Faculty of Pharmaceutical Sciences, Josai University
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Uematsu T
Department Of Pharmacology Gifu University School Of Medicine
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Uematsu Toshihiko
Department Of Pharmacology Gifu University
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Niwa Masayuki
Department Of Pharmacology Gifu University School Of Medicine
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Kawase Masami
Faculty Of Pharmaceutical Sciences Josai University
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Sunaga Katsuyoshi
Faculty Of Phamaceutical Sciences Josai University
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Sunaga Katsuyoshi
Faculty Of Pharmaceutical Sciences Josai University
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