EFFECTS OF PHENYLEPHRINE AND ISOPROTERENOL ON THE ACTIVITY OF CYCLIC AMP-DEPENDENT PROTEIN KINASE OF HYPOTHYROID RAT TISSUES
スポンサーリンク
概要
- 論文の詳細を見る
The present study was designed to examine the properties of cyclic AMP-dependent protein kinase from normal and hypothyroid rat tissues. The activity of the liver enzyme decreased in hypothyroid rats and this reduced activity may be due to the decrease in synthesis of enzyme protein. The enzyme activity from the kidney of hypothyroid rats increased by 35% in the absence of cyclic AMP. Further, the enzyme from the kidney of hypothyroid animals responded to phenylephrine and isoproterenol. In the heart, the basal enzyme activity was the same in both groups, but the enzyme from the heart of hypothyroid animals did not respond to isoproterenol. When hypothyroid rats were treated with 3, 3, 5-triiodothyronine, the enzyme activities from those rat tissues showed essentially the same level as those of the corresponding normal ones. These results suggest that thyroid hormone regulates adrenergic agonists-mediated responses both at the sites of adrenoceptors and that of protein phosphorylation. Furthermore, the dependence on thyroid hormone varies according to the tissue.
- 社団法人 日本薬理学会の論文
著者
-
Uematsu Toshihiko
Department Of Pharmacology Gifu University
-
HAGINO Yasumichi
Department of Pharmacology, Fujita Health University School of Medicine
-
TACHIBANA MASAKATSU
Department of Pharmacology, Fujita-Gakuen Health University School of Medicine
-
Tachibana Masakatsu
Department Of Pharmacology Fujita-gakuen Health University School Of Medicine
-
HAGINO Yasumichi
Department of Biochemistry, Nagoya University School of Medicine
-
HAGINO Yasumichi
Department of Pharmacology, Nagoya Unirersity School of Medicine
-
UEMATSU Toshihiko
Department of Pharmacology, Nagoya Unirersity School of Medicine
関連論文
- Trifluoromethyl Ketone-based Inhibitors of Apoptosis inCerebellar Granule Neurons
- PRODUCTION OF AORTIC INSUFFICIENCY OR MYOCARDIAL INFARCT IN THE RAT AND SUBSEQUENT MYOCARDIAL HYPERTROPHY : CHANGES IN ADRENOCEPTORS WITH SPECIAL REFERENCE TO THE RELATION BETWEEN RECEPTOR DENSITY AND CONTRACTILE RESPONSE
- Trifluoromethyl Ketone-Based Inhibitors of Apoptosis in Cerebellar Granule Neurons
- Metabolic Effects of Glibenclamide in Isolated Rat Hepatocytes in the Absence of Extracellular Ca^
- An Experimental Myocardial Infarction Model in the Rat and Its Properties
- cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells
- Sex Difference in Sensitivity to α-Adrenergic Drugs in Blood Vessels of SHR Hindlimb
- Sex-Dependent Difference in Sensitivity to Adrenergic Agents in the Blood Vessels of SHR Hindlimb
- INCIDENCE OF EPINEPHRINE-INDUCED PULMONARY EDEMA IN RABBITS AND ACCOMPANYING METABOLIC CHANGES
- -66-EFFECTS OF A NEW CLASS I ANTIARRHYTHMIC AGENT SA3212 ON ARRHYTHMIA OCCURED 24 HOURS AFTER THE CORONARY LIGATION AND INTRAVENTRICULAR DELAYED CONDUCTION 7 DAYS AFTER THE LIGATION IN CANINE : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53t
- REGULATION OF HEPATIC METABOLISM BY NEUROPEPTIDES
- EFFECT OF ADRENERGIC AGONISTS ON THE CYCLIC AMP LEVEL IN THE LIVER AND HEART FROM NORMAL AND HYPOTHYROID RATS
- ANALYSIS OF DRUGS AND ENDOGENOUS SUBSTANCES IN HUMAN HAIR FOR ASSESSING INDIVIDUAL PAST HISTORY OF DRUG THERAPY AND PROGRESS OF DISEASE STATE
- EFFECT OF HYPOTHYROID STATUS ON ADENOSINE 3, 5-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE OF RAT KIDNEY
- EFFECTS OF PHENYLEPHRINE AND ISOPROTERENOL ON THE ACTIVITY OF CYCLIC AMP-DEPENDENT PROTEIN KINASE OF HYPOTHYROID RAT TISSUES
- AMYLASE RELEASE FROM PAROTID GLANDS OF HYPOTHYROID RATS II. PHOSPHORYLATION OF MICROSOMAL PROTEINS AND EFFECTS OF ADENOSINE 3, 5-MONOPHOSPHATE AND TOLBUTAMIDE
- EFFECT OF HYPOTHYROID STATUS ON ADENOSINE 3, 5-MONO-PHOSPHATE-DEPENDENT PROTEIN KINASE OF SKELETAL, HEART AND DIAPHRAGM MUSCLE OF RATS
- EFFECT OF THYROID HORMONE ON CYCLIC AMP PHOSPHODIESTERASE IN RAT KIDNEY
- ADRENERGIC RECEPTORS IN RAT LIVER : II. EFFECTS OF PHENYLEPHRINE, ISOPROTERENOL AND ADRENERGIC BLOCKING AGENTS ON GLUCONEOGENESIS IN PERFUSED LIVER
- ADRENERGIC RECEPTORS IN RAT LIVER : I. EFFECTS OF EPINEPHRINE AND ADRENERGIC BLOCKING AGENTS ON GLUCONEOGENESIS IN PERFUSED LIVER
- AMYLASE RELEASE FROM PAROTID GLANDS OF HYPOTHYROID RATS I. ALTERED RESPONSIVENESS TO ADRENERGIC AGENTS
- EVIDENCE FOR THE EXISTENCE OF ALPHA ADRENERGIC RECEPTOR IN ISOLATED RAT ATRIA
- EFFECT OF HYPOTHYROID STATUS ON MYOCARDIAL RESPONSES TO SYMPATHOMIMETIC DRUGS
- GRAPHICAL ANALYSIS OF DRUG EFFECTS IN THE DOG HEART-LUNG PREPARATION-WITH PARTICULAR REFERENCE TO THE PULMONARY CIRCULATION AND EFFECTS OF NOREPINEPHRINE AND 5-HYDROXYTRYPTAMINE
- Direct Recording of Cardiac Output- and Venous Return-Curves in the Dog Heart-Lung Preparation for a Graphical Analysis of the Effects of Cardioactive Drugs
- Adenosine 3',5'-monophosphate dependent protein kinase of uterus in euthyroid and hypothyroid rats.
- The role of calcium ion in methoxamine-induced amylase release from parotid glands of euthyroid and hypothyroid rats.
- Changes in plasma level of alpha-atrial natriuretic polypeptide (alpha-ANP) and responsiveness of the aorta to exogenous alpha-ANP subsequent to myocardial infarction in rats.
- Changes in vascular responsiveness to vasoactive agents in the hindlimb of DOCA-salt hypertensive rats.
- Effect of Ibudilast on Microcirculation Thrombosis in Rat Inner Ear.
- Time course of the development of pre- and postjunctional supersensitivity in the rabbit ear artery after decentralization.
- Effects of vasopressin, angiotensin II and phenylephrine on hepatic ketogenesis and fatty acid synthesis.
- Heterogeneity in vasorelaxant effects of .ALPHA.-human atrial natriuretic polypeptide in the dog.
- Increases in alpha-but not beta-adrenoceptors in hypertrophied non-infarcted cardiac muscles from rats with chronic myocardial infarction.
- The interaction of .ALPHA.- and .BETA.-adrenergic agonists on amylase release from parotid glands of euthyroid and hypothyroid rats.
- Studies on the Sensitivity to α-Adrenergic Agents in Blood Vessels of SHR Hindlimb
- Effects of mepacrine on the oxidation of (1-14C)oleate in isolated rat hepatocytes.