Changes in vascular responsiveness to vasoactive agents in the hindlimb of DOCA-salt hypertensive rats.
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概要
- 論文の詳細を見る
The responsiveness to vasoactive agents in the perfused hindlimb of DOCA-salt hypertensive rats was examined and compared with that of normotensive rats. The vasoconstrictor responses in the femoral vascular bed to norepinephrine and serotonin were markedly potentiated in DOCA-salt hypertensive rats as compared with those in normotensive rats, and no change was found in the responses to angiotensin II. On the other hand, the vasodilatory response in DOCA-salt hypertensive rats to isoproterenol was attenuated without any marked changes in responsiveness to acetylcholine, nitroprusside and papaverine. These results suggested that the reduced vasodilator responses as well as the increased vasoconstrictor responses occur to some specific vasoactive agents in DOCA-salt hypertensive rats.
- 公益社団法人 日本薬理学会の論文
著者
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Uematsu Toshihiko
Department Of Pharmacology Gifu University
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Nakashima Mitsuyoshi
Deparrment Of Pharmacology Hamamatsu University School Of Medicine
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Ozaki Tohru
Department Of Pharmacology Hamamatsu University School Of Medicine
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Hashimoto Hisakuni
Department Of Pharmacology Hamamatsu University School Of Medicine
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SOGABE KEIZO
Department of Pharmacology, Hamamatsu University School of Medicine
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Ozaki Tohru
Department of Pharmacology, Hamamatsu University School of Medicine
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