Noninvasive Evaluation of Cardiovascular Effects of β-Adrenergic Blockers with Different Pharmacological Properties
スポンサーリンク
概要
- 論文の詳細を見る
The effects of nadolol (Nad), indenolol (Idn), metoprolol (Met), pindolol (Pid), arotinolol (Art, S-596), and propranolol (Prp) on the cardiovascular system were studied noninvasively in healthy male volunteers. Exercise testing. with a bicycle ergometer was performed both before and after single oral administration of these β-blockers, and any changes in the exercise induced increase in heart rate systolic blood pressure product (ΔDP) were studied. Systolic time intervals were measured from the simultaneous recording of carotid pulse, phonocardiogram, and electrocardiogram at rest. Left ventricular dimensions were measured by echocardiography, and ejection fraction (EF), stroke index (SI), and cardiac index (CI) were calculated by the standard techniques. Systemic vascular resistance (SVR) was computed from these data. ΔDP was decreased with all β-blockers. According to the degree of this effect, the relative potency of these drugs was estimated to be as follows: Pid > Art> Idn≒Prp> Nad ≒ Met. The ratio of pre-ejection period to left ventricular ejection time was increased with all β-blockers. EF, SI, and CI were decreased by all β-blockers except Pid, by which SI and CI were kept almost unchanged, and EF was significantly increased. Therefore, Pid was thought to be less cardiosuppressive than the other β-blockers. SVR was significantly decreased by Pid, while it was increased by all the other β-blockers. These results suggest that the acute hemodynamic response to β-blockers is determined primarily by the property of intrinsic sympathomimetic activity. Neither β1-selectivity nor membrane stabilizing effect was shown to be a major factor modifying the central or peripheral hemodynamic response to β-blockers.rights ：日本臨床薬理学会rights ：本文データは学協会の許諾に基づきJournal archiveから複製したものである
- 日本臨床薬理学会の論文
著者
-
Nakashima Mitsuyoshi
Deparrment Of Pharmacology Hamamatsu University School Of Medicine
-
Takiguchi Yoshiharu
Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad
-
Hashimoto Hisakuni
Department Of Pharmacology Hamamatsu University School Of Medicine
-
HASHIMOTO Hisakuni
Department of Pharmacology, Hamamatsu University School of Medicine
-
OGURO Katsunori
Department of Pharmacology and Experimental Therapeutics, Tohoku University School of Medicine
-
Ohguchi Sadao
Department of Pharmacology, Hamamatsu University School of Medicine
関連論文
- The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
- ラット4型コラーゲンの組換えNC1抗原感作による糸球体腎炎モデルにおける腎機能および組織構造の変化
- PHARMACOKINETICS OF PLASMA AND URINE CLENBUTEROL IN MAN, RAT, AND RABBIT
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Formation of Systemic Hemoglobin-Nitric Oxide Complex (HbNO) From Dietary Nitrite
- S12-4 Zinc-induced cytotoxicity in PC12 cells(SYMPOSIUM 12: OXIDATIVE STRESS AND ORGAN DAMAGE)(Proceedings of the 31st Annual Meeting)
- Clinical Effects of Rosuvastatin, a New HMG-CoA Reductase Inhibitor, in Japanese Patients With Primary Hypercholesterolemia : an Early Phase II Study
- A randomized open-label comparative study of conventional therapy versus mizoribine onlay therapy in patients with steroid-resistant nephrotic syndrome (postmarketing survey)
- Long-term Effects of Nifedipine Retard vs ACE Inhibitors in Hypertension with Coronary Artery Disease : Final Reports of J-MIC(B)
- -P118-ENDOTHELIN ENHANCES ADRENERGIC VASOCONSTRICTION IN RAT : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- BLOOD PRESSURE RESPONSE TO [1-SARCOSINE, 8-ISOLEUCINE]ANGIOTENSIN II IN PATIENTS WITH LIVER CIRRHOSIS AND ASCITES
- PRODUCTION OF AORTIC INSUFFICIENCY OR MYOCARDIAL INFARCT IN THE RAT AND SUBSEQUENT MYOCARDIAL HYPERTROPHY : CHANGES IN ADRENOCEPTORS WITH SPECIAL REFERENCE TO THE RELATION BETWEEN RECEPTOR DENSITY AND CONTRACTILE RESPONSE
- Randomized Double-Blind Trial of Intracoronary Urokinase for Acute Myocardial Infarction : Multicenter Study : 50th Annual Scientific Session of the Japanese Circulation Society
- Electrophysiologic Effects of Nitrous Oxide, a Volatile Anesthetic, in Dogs Following Myocardial Infarction in Comparison with Other Anesthetics
- Comparison of the Effects of Halothane and Propranolol on the Effective Refractory Period and the Ventricular Activation in a Canine Myocardial Infarction Model
- -1048-ENDOTHELIN RELEASE FORM PERFUSED RAT MESENTERIC ARTERY ENHANCED BY HYPOXIA : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE EFFECT OF AGE ON ACTIVE AND CRYOACTIVATABLE INACTIVE PLASMA RENIN IN NORMAL SUBJECTS AND PATIENTS WITH ESSENTIAL HYPERTENSION
- -272-STUDIES ON PATHOGENESIS OF HYPERTENSION AND BLOOD PRESSURE MAINTENANCE IN HUMAN BY THE USE OF ANGIOTENSIN II ANALOGUES : Renin,Angiotensin : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Phase I Clinical Studies of S-1090: Safety and Pharmacokinetics
- -441- HEMODYNAMIC, RENAL AND HORMONAL EFFECTS OF α-HUMAN ATRIAL NATRIURETIC PEPTIDE INJECTION IN PATIENTS WITH CONGESTIVE HEART FAILURE
- A Placebo-Controlled, Single-Blind Study to Determine the Appropriate Alendronate Dosage in Postmenopausal Japanese Patients with Osteopotosis
- -P121-ENDOTHELIN INHIBITS RENIN RELEASE FROM ISOLATED RAT GLOMERULI : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EFFECT OF CAPTOPRIL ON RENAL VASCULAR RESISTENCE, RENIN, PROSTAGLANDINS AND KININ IN THE ISOLATED PERFUSED KIDNEY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
- EFFECT OF AGING ON 6-keto-PGF_ LEVELS IN NORMOTENSIVE AND ESSENTIAL HYPERTENSIVE MALES
- HYPOTENSIVE ACTIVITY OF SYNTHETIC RENOMEDULLARY ANTIHYPERTENSIVE LIPID, 1-0-HEXADECYL-2-0-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- THE PESPONSES OF ACTIVE AND INACTIVE PLASMA RENIN TO VARIOUS CONDITIONS AND THE POSSIBLE ROLE OF PLASMA OR RENAL KALLIKREIN IN ACTIVATION OF INACTIVE RENIN : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Cir
- Difference in the Incidence of Cough Induced by Angiotensin Converting Enzyme Inhibitors: a Comparative Study Using Imidapril Hydrochloride and Enalapril Maleate
- An Experimental Myocardial Infarction Model in the Rat and Its Properties
- Comparison of Antibacterial Activity of Fluoroquinolones with Their Sucralfate-complexes against Clinically-isolated Bacteria
- Effects of Astemizole on Ventricular Activation Delay and RT Intervals in a Canine Myocardial Infarction Model
- Comparison of the Protective Effect of N-Acetylcysteine by Different Treatments on Rat Myocardial Ischemia-Reperfusion Injury
- Automated sampling system for long-term monitoring of nitrous oxide and methane fluxes from soils(Environment)
- Effect of Argatroban on Microthrombi Formation and Brain Damage in the Rat Middle Cerebral Artery Thrombosis Model
- Inhibitory Effect of Clopidogrel, Vapiprost and Argatroban on the Middle Cerebral Artery Thrombosis in the Rat
- Altered Prostaglandin Metabolism Induced by Angiotensin-Converting Enzyme Inhibitors in Broncho-Alveolar Lavage Fluid of the Guinea Pig
- A Differential Alteration in the Responsiveness of Isolated Cardiac Muscles to Alpha-and Beta-adrenergic Agonists in DOCA-Salt Hypertensive Rats
- Recommended initial loading dose of teicoplanin, established by therapeutic drug monitoring, and outcome in terms of optimal trough level
- Change of the Blood Concentration of Tacrolimus after the Switch from Fluconazole to Voriconazole in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation(Biopharmacy)
- Effects of antidepressants trazodone, dosulepin and amitriptyline on cardiac conduction in the canine heart after myocardial infarction
- Effects of Amorphous and Polymorphs of PF1022A, a New Antinematode Drug, on Angiostrongylus costaricensis in Mice
- -66-EFFECTS OF A NEW CLASS I ANTIARRHYTHMIC AGENT SA3212 ON ARRHYTHMIA OCCURED 24 HOURS AFTER THE CORONARY LIGATION AND INTRAVENTRICULAR DELAYED CONDUCTION 7 DAYS AFTER THE LIGATION IN CANINE : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53t
- Effects of antiarrythmic drugs on excitation and conduction abnormalities in various stages of myocardial ischemia in experimental animals
- Optimal dosage and differences in therapeutic efficacy of IGIV in Kawasaki disease
- Single Exposure to Gasoline or Ether Reduces Cytochrome P-450 Activities without Affecting UDP-Glucuronosyltransferase Activity in Rat Liver
- INFLUENCE OF HYPOTHYROID STATUS ON DOPAMINEIN-DUCED POSITIVE CHRONOTROPIC AND INOTROPIC EFFECTS ON ISOLATED RAT ATRIA
- ANTI-ARRHYTMIC EFFECT OF NADOLOL IN EXPERIMENTAL ARRHYTHMIAS : COMPARISON WITH PROPRANOLOL AND ALPRENOLOL
- STIMULANT ACTION OF METHOXAMINE IN THE ISOLATED ATRIA OF NORMAL AND 6-PROPYL-2-THIOURACIL-FED RATS
- ADRENERGIC RECEPTORS IN RAT LIVER : II. EFFECTS OF PHENYLEPHRINE, ISOPROTERENOL AND ADRENERGIC BLOCKING AGENTS ON GLUCONEOGENESIS IN PERFUSED LIVER
- ADRENERGIC RECEPTORS IN RAT LIVER : I. EFFECTS OF EPINEPHRINE AND ADRENERGIC BLOCKING AGENTS ON GLUCONEOGENESIS IN PERFUSED LIVER
- Clinical Evaluation of a New Formula of Timolol Maleate (WP-934 Ophthalmic Solution)
- EVIDENCE FOR THE EXISTENCE OF ALPHA ADRENERGIC RECEPTOR IN ISOLATED RAT ATRIA
- EFFECT OF HYPOTHYROID STATUS ON MYOCARDIAL RESPONSES TO SYMPATHOMIMETIC DRUGS
- Experimental Studies and Clinical Report on the Electrical Alternans of ST Segment during Myocardial Ischemia
- Effect of Calcium Antagonists on the Electrical Alternans of the ST Segment during Acute Coronary Occlusion in Dogs
- STUDIES ON THE VASCULAR ACTION OF BRADYKININ
- Effects of 2-((5-chloro-2-methoxyphenyl)azo)-1H-imidazole (M6434) on alpha adrenergic receptors.
- EFFECTS OF VARIOUS CORONARY VASODILATORS ON MYOCARDIAL OXYGEN CONSUMPTION
- Noninvasive Evaluation of Cardiovascular Effects of β-Adrenergic Blockers with Different Pharmacological Properties
- Changes by hypertension and hypercholesterolemia in arterial enzyme activities in the rat
- Electrophysiologic Interaction between Class I Antiarrhythmic Drugs and Volatile Anesthetics in Depressant Effects on Ventricular Activation in a Canine Myocardial Infarction Model.
- Changes in plasma level of alpha-atrial natriuretic polypeptide (alpha-ANP) and responsiveness of the aorta to exogenous alpha-ANP subsequent to myocardial infarction in rats.
- Changes in vascular responsiveness to vasoactive agents in the hindlimb of DOCA-salt hypertensive rats.
- Effect of Ibudilast on Microcirculation Thrombosis in Rat Inner Ear.
- Changes in aortic lysosomal enzyme activities by DOCA-salt and renal hypertension in the rat-comparison with spontaneous hypertension
- Effects of hypertension superimposed by hypercholesterolemia on arterial enzyme activities in SHRSP
- Changes in the effects of clonidine on left atrium and hindlimb vasculature of rats in various thyroid states. A study of the responsiveness of .ALPHA.2-adrenoceptors in the cardiovascular system.:A Study of the Responsiveness of α2-Adrenoceptors in the C
- PHARMACOLOGIC ANALYSIS OF THE RESPONSE TO THYMOXAMINE (6-ACETOXYTHYMOXY-ETHYL-DIMETHYLAMINE) ON THE SINOATRIAL NODE OF THE DOG HEART
- Evaluation of a Noninvasive Automatic Continuous Systolic Blood Pressure Monitor and a Noninvasive Deep Body Ther mometer for Clinical Trials:Comparison of Three Acute Hypotension Cases
- Heterogeneity in vasorelaxant effects of .ALPHA.-human atrial natriuretic polypeptide in the dog.