The interaction of .ALPHA.- and .BETA.-adrenergic agonists on amylase release from parotid glands of euthyroid and hypothyroid rats.
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概要
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The interaction between α- and β-adrenergic agonists was examined with respect to amylase release from rat parotid glands. The effect of hypothyroid status on this interaction was also compared with that in euthyroid rats. Both methoxamine and clonidine potentiated isoproterenol-induced amylase release from parotid glands of eu- and hypothyroid rats, but the α<SUB>2</SUB>-adrenoceptor-mediated response disappeared in the hypothyroid rats. Dibutyryl cyclic AMP, a second messenger of β-adrenergic agonists, also showed essentially the same results as those of isoproterenol, but potentiation of dibutyryl cyclic AMP-induced amylase release with α-adrenergic agonists was mediated through only α<SUB>1</SUB>-adrenoceptors in both groups. Calcium ion plays an important role in the interaction between α- and β-adrenergic agonists. These results suggest that the potentiating effect of α-adrenergic agonists may be mediated at least in part through an unknown mechanism at the step distal to cyclic AMP formation in both eu and hypothyroid rats.
- 公益社団法人 日本薬理学会の論文
著者
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Tachibana Masakatsu
Department Of Pharmacology Fujita-gakuen Health University School Of Medicine
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Nomura Takahide
Department Of Pharmacology School Of Medicine Fujita Health University
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Nomura Hiroko
Department Of Applied Chemistry Faculty Of Science And Engineering Chuo University
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HAGINO Yasumichi
Department of Biochemistry, Nagoya University School of Medicine
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IZUHARA Ken
Department of Pharmacology, Fuiita-Gakuen Health University School of Medicine
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NOMURA Hiroko
Department of Pharmacology, Fuiita-Gakuen Health University School of Medicine
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KODAMA Mitsushi
Department of Pharmacology, Fuiita-Gakuen Health University School of Medicine
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SUGIURA Nobuki
Department of Pharmacology, Fuiita-Gakuen Health University School of Medicine
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