Convenient Synthesis of α-Trifluoromethylated Acyloins from α-Hydroxy or α-Amino Acids
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概要
- 論文の詳細を見る
α-Trifluoromethylated acyloins (2 and 6) have been prepared from α-hydroxy acids (1), N-acylprolines (5) or N-acyl-N-alkyl α-amino acids (8) by novel transformation reactions with trifluoroacetic anhydride (TFAA) in the presence of pyridine. The former reaction of 1 could proceed through mesoionic 1,3-dioxolium-4-olates, whereas the latter two reactions of α-amino acids (5 and 8) could involve mesoionic 1,3-oxazolium-5-olates. The reaction of 1 with TFAA shows more potential for practical applications because of the ready availability of the starting materials and ease of manipulation.
- 公益社団法人日本薬学会の論文
- 2000-09-01
著者
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Saito Setsuo
Faculty of Pharmaceutical Science,Josai University
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Kurihara T
Josai Univ. Saitama Jpn
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Kurihara Teruo
Faculty Of Science Josai University
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KAWASE Masami
Faculty of Pharmaceutical Sciences, Josai University
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Kawase M
Faculty Of Pharmaceutical Sciences Josai University
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Kawase Masami
Faculty Of Pharmaceutical Sciences Josai University
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Saito S
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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