Inhibitory Effect of Mao-Bushi-Saishin-to on Prostaglandin E_2 Synthesis in C6 Rat Glioma Cells(Pharmacology)
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概要
- 論文の詳細を見る
Effect of Mao-Bushi-Saishin-to (Ma-Huang-Fu-Zi-Xi-Xin-Tang: MBS) on prostaglandin E_2 (PGE_2) production was investigated using C6 rat glioma cells. Mao or Saishin inhibited histamine-induced PGE_2 production while MBS slightly decreased and Bushi increased it. MBS and Mao inhibited and Bushi enhanced A23187-induced PGE_2 production while Saishin had no effect. Concomitantly, Mao inhibted, but Bushi fascilitated, histamine- and A23187-induced phosphorylation of extracellular signal-regulated kinase (ERK)1/2. Treatment of MBS, Mao and also Saishin increased CAMP content. From these results, MBS inhibit PGE_2 production in C6 cells, mainly due to Mao but also due to Saishin at least in part, and the counteraction of Bushi. The former effect is mediated by formation of CAMP and resulting inhibition of ERK1/2-phosphorylation.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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Nakahata Norimichi
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Jap
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Oda Mayumi
Department Of Pharmaceutical Molecular Biology Tohoku University
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OHIZUMI Yasushi
Graduate School of Pharmaceutical Sciences, Tohoku University
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Saito Shin-ya
Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku Universit
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Oshima Yasukatsu
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Yasushi Ohizumi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Saito Shin-ya
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Saito S
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Nakahata N
Department Of Cellular Signaling Graduate School Of Pharmaceutical Sciences Tohoku University
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Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
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Nakahata Norimichi
Inst. For International Advanced Res. And Education Tohoku Univ. International Advanced Res. And Edu
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KAMIYAMA Sachie
Department of Pharmaceutical Molecular Biology, Tohoku University
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Kamiyama Sachie
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Saito Shin-ya
Department Of Pharmaceutical Molecular Bio1ogy Facu1ry Of Pharmaceutical Sciences Tohoku Universiry
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