Ephedorae herba Decreases Lipopolysaccharide-Induced Cyclooxgenase-2 Protein Expression and NF-κB-Dependent Transcription in C6 Rat Glioma Cells
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概要
- 論文の詳細を見る
We studied the effects of Mao (Ephedrae herba) on lipopolysaccharide (LPS)-induced expression of inducible cyclooxygenase (COX-2) in C6 rat glioma cells. Western blot analysis showed that Mao inhibited LPS-induced expression of COX-2 protein, but not that of constitutive cyclooxygenase. Reporter gene assays showed that Mao reduced LPS-inducible NF-κB-dependent transcription that plays a crucial role in induction of COX-2 gene expression. This crude drug decreased LPS-induced IκBα degradation in a concentration-dependent manner without affecting LPS-induced IκB phosphorylation. These results suggest that Mao prevents LPS-induced NF-κB-dependent transcription by inhibiting IκB degradation and suppresses an increase in COX-2 protein expression in C6 cells.
- 社団法人 日本薬理学会の論文
- 2005-07-20
著者
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YOSHIDA Masaaki
Research Laboratory, Kotaro Pharmaceutical Co., Ltd
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Yamakuni Tohru
Tohoku Univ. Sendai Jpn
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Yamakuni Tohru
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Science Tohoku Univ
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Oshima Yasukatsu
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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AOKI Kohichi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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Yoshida Masaaki
Research Laboratory Kotaro Pharmaceutical Co. Ltd
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Ohizumi Yasushi
Univ. Shizuoka Shizuoka Jpn
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Aoki Kohichi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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