Nardosinone Enhances Nerve Growth Factor-Induced Neurite Outgrowth in a Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Manner in PC12D Cells
スポンサーリンク
概要
- 論文の詳細を見る
The mechanism to enhance nerve growth factor (NGF, 2 ng/ml)-induced neurite outgrowth from PC12D cells by nardosinone isolated from Nardostachys chinensis was examined. It was shown that the potentiation of the NGF-induced neurite outgrowth by nardosinone was mitogen-activated protein (MAP) kinase-dependent, but was not accompanied by stimulation of NGF-induced increase in MAP kinase phosphorylation. Furthermore, this augmentation of NGF-induced neurite outgrowth was abolished by GF109203X, a protein kinase C (PKC) inhibitor. These results suggest that the enhancement of NGF-induced neurite outgrowth from PC12D cells by nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC.
- 社団法人 日本薬理学会の論文
- 2003-09-01
著者
-
Matsunaga Keiji
Graduate School Of Pharmaceutical Sciences Kyoto University
-
OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
-
YAMAKUNI TOHRU
Departments of Neuropharmacology, Brain Research Institute, Niigata University
-
LI Ping
Department of Cell Biology Institute of Nephrology, Niigata University School of Medicine
-
Li Ping
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Yamakuni Tohru
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Science Tohoku Univ
-
OHIZUMI Yasushi
Graduate School of Pharmaceutical Sciences, Tohoku University
-
MATSUNAGA Kimihiro
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
-
Yasushi Ohizumi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Matsunaga Kazuhisa
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Matsunaga K
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Matsunaga Kimihiro
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences
-
KONDO Shunzo
Mitsubishi Kagaku Institute of Life Sciences
-
Li Ping
Department Of Cardiology Nagoya University Gradute School Of Medicine
-
Li P
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Kondo Shunzo
Mitsubishi Kagaku Inst. Of Life Sci. Tokyo Jpn
-
Yamakuni Tohru
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
-
Matsunaga Kimihiro
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
-
Mihashi Kunihide
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Matsunaga Kimihiro
Department of Applied Biological Sciences, Faculty of Agriculture, Saga University
関連論文
- Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, inhibits IgE-mediated histamine release from rat RBL-2H3 basophilic leukocyte cells
- Structural Revisions of Blumenol C Glucoside and Byzantionoside B
- A PURKINJE CELL-SPECIFIC PROTEIN (SPOT 35 PROTEIN) SHOWING WIDE DISTRIBUTION IN THE ENDOCRINE SYSTEM OF SOME MAMMALS. AN IMMUNOHISTOCHEMICAL STUDY
- Tricalysionoside A, a Megastigmane Gentiobioside, Sulfatricalysines A—F, and Tricalysiosides X—Z, ent-Kaurane Glucosides, from the Leaves of Tricalysia dubia
- Suppressive effects of Sairei-to on monoclonal antibody 1-22-3-induced glomerulonephritis : Analysis of effective components
- Reinvestigation of the Absolute Stereochemistry of Megastigmane Glucoside, Icariside B5
- α-Mangostin Induces Ca^-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
- Antiproliferative Constituents from Umbelliferae Plants. V. A New Furanocoumarin and Falcarindiol Furanocoumarin Ethers from the Root of Angelica japonica
- An Immunohistochemical Analysis of p27 Expression in Human Pancreatic Carcinomas
- Comparison of Several Mixing Rules in Equations of State for Calculating Solid-Solubilities in Supercritical Fluids
- OE-137 Important Role of the Bradykinin B2 Receptor Axis in Imidapril-mediated Therapeutic Angiogenesis in AT1 Receptor Knockout Mice(Peripheral circulation-1 (H) OE23,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japan
- 4 Pioglitazone Attenuates Angiotensin II-Induced Cardiac Hypertrophy and Fibrosis through Stimulation of Adiponectin Secretion(Young Investigator's Award for International Students Finalists Lecture (YIA International),The 73rd Annual Scientific Meeting o
- PJ-706 MMP-2 Deficiency Attenuates Ischemia-induced Angiogenesis and Vasculogenesis in MMP-2-Deficient Mice(Regeneration (angionenesis/myocardial regeneration)-7 (M) PJ119,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Jap
- New Sesquiterpene Hydroperoxides with Trypanocidal Activity from Pogostemon cablin
- New Norditerpenoids with Trypanocidal Activity from Vitex trifolia
- Trypanocidal Flavonoids from Sophora flavescens
- Flavonoid Constituents of Dracocephalum kotschyi Growing in Iran and Their Trypanocidal Activity
- Trypanocidal Terpenoids from Laurus nobilis L.
- Screening of Natural Medicines Used in Vietnam for Trypanocidal Activity against Epimastigotes of Trypanosoma cruzi
- Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica(Pharmacognosy)
- 2SB1420 天然変性ペプチドCARMILによるアクチンキャッピングプロテインの活性制御機構(2SB 天然変性タンパク質の構造、物性、機能,第48回日本生物物理学会年会)
- 1P008 Two Distinct Mechanisms for Actin Capping Protein Regulation- Steric and Allosteric Inhibition(Protein:Structure,The 48th Annual Meeting of the Biophysical Society of Japan)
- Lignan and neolignan glucosides, and tachioside 2'-O-4"-O-methylgallate from the leaves of Glochidion rubrum
- Search for Constituents with Neurotrophic Factor-Potentiating Activity from the Medicinal Plants of Paraguay and Thailand
- The Mechanism of Rabbit Platelet Aggregation Induced by 2,5-Di-(tert-butyl)-1,4-benzohydroquinone, an Inhibitor of Endoplasmic Reticulum Ca^-ATPase
- The Mode of Inhibitory Action of α-Mangostin, a Novel Inhibitor, on the Sarcoplasmic Reticulum Ca^-Pumping ATPase from Rabbit Skeletal Muscle
- Two New Monoterpene Peroxide Glycosides from Aster scaber
- Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
- Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice
- Chemical constituents of imported Rosae fructus
- Schefflerins A—G, New Triterpene Glucosides from the Leaves of Schefflera arboricola
- Iridoids and Anthraquinones from the Malaysian Medicinal Plant, Saprosma scortechinii (Rubiaceae)
- Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on Intracellular Ca^ Mobilization in C6 Rat Glioma Cells
- Antiproliferative Constituents from Umbelliferae Plants. IX. New Triterpenoid Glycosides from the Fruits of Bupleurum rotundifolium
- Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleunim rotundifolium
- Inhibitions of Histamine Release and Prostaglandin E_2 Synthesis by Mangosteen, a Thai Medicinal Plant
- Nardosinone Enhances Nerve Growth Factor-Induced Neurite Outgrowth in a Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Manner in PC12D Cells
- Nerve Growth Factor-Potentiating Compounds from Picrorhizae Rhizoma
- Enhancement of the Nerve Growth Factor-Mediated Neurite Outgrowth from PC12D Cells by Chinese and Paraguayan Medicinal Plants
- The Powerful Stimulatory Action of 6-O-Acetyl-9-methyl-7-bromoeudistomin D on the Contractile Protein System of Rabbit Skeletal Muscle
- Inhibitory Effect of Mao-Bushi-Saishin-to on Prostaglandin E_2 Synthesis in C6 Rat Glioma Cells(Pharmacology)
- Ephedrae herba in Mao-Bushi-Saishin-To Inhibits IgE-Mediated Histamine Release and Increases cAMP Content in RBL-2H3 Cells
- Inhibition of Microtubule Polymerization by SK&F 96365, a Blocker of Receptor-Linked Ca^ Entry
- A Novel Diol-derivative of Chalcone Produced by Bioconversion, 3-(2,3-Dihydroxyphenyl)-1-phenylpropan-1-one, Activates Phosphorylation of ERK and CREB in Cultured Rat Cortical Neurons
- Littorachalcone, a New Enhancer of NGF-Mediated Neurite Outgrowth, from Verbena littoralis
- Structure Activity Relationship and Molecular Modeling Analysis of Nantenine Derivatives in 5-HT_ and α_ Receptor Antagonistic Activities
- Constituents of a Paraguayan Medicinal Plant Verbena littoralis H. B. K.
- The Behavior of Dihydropyrazine with DNA Strand-Breakage Activity in Vivo(Biochemistry/Molecular Biology)
- Prodrugs for Systemic Bioreductive Activation-Independent Delivery of Phyllohydroquinone, an Active Form of Phylloquinone (Vitamin K_1)1 : Preparation and in Vitro Evaluation
- Tumor scintigraphy by the method for subtracting the initial image with technetium-99m labeled antibody
- Prodrug for Bioreductive Activation-Independent Delivery of Menahydroquinone-4 : Human Liver Enzymatic Activation and Its Action in Warfarin-Poisoned Human Liver
- The Combination of Rat Mast Cell and Rabbit Aortic Smooth Muscle Is the Simple Bioassay for the Screening of Anti-allergic Ingreditent from Methanolic Extract of Corydalis Tuber(Pharmacognosy)
- Ephedrae herba (Mao) decreased histamine content in RBL-2H3 cells
- Clerodane Diterpenoids and Flavonoids with NGF-Potentiating Activity from the Aerial Parts of Baccharis gaudichaudiana
- A Method to Compute All Fixed Points of Iterative MUD of IDMA Systems
- Xanthones with NGF-potentiating activity
- Prenylated Xanthones from Garcinia xanthochymus
- A New Iridoid Glycoside with Nerve Growth Factor-Potentiating Activity, Gelsemiol 6'-trans-Caffeoyl-1-glucoside, from Verbena littoralis
- Early lexical development in a self-organizing neural network
- Medicinal Plants of Thailand. I Structures of Rheedeiosides A—D and cis-Entadamide A β-D-Glucopyranoside from the Seed Kernels of Entada rheedei
- Crotalionosides A—C, Three New Megastigmane Glucosides, Two New Pterocarpan Glucosides and a Chalcone C-Glucoside from the Whole Plants of Crotalaria zanzibarica
- Supinaionosides A and B: Megastigmane Glucosides and Supinanitrilosides A—F: Hydroxynitrile Glucosides from the Whole Plants of Euphorbia supina RAFINESQUE
- Detection of Numerical Chromosome Abnormalities in Human Spermatozoa by Three-Color Fluorescence in situ Hybridization
- A Direction-Dependent Mobile Terminal Sleep Mode Operation Scheme(Network)
- A Dynamic Mobile Terminal Sleep Mode Operation Scheme Considering Packet Queue Length(Network)
- Iridoids and Sesquiterpenoids with NGF-Potentiating Activity from the Rhizomes and Roots of Valeriana fauriei
- Flavonoid Glycosides from Cecropia adenopus
- Naphthoquinone and Iridoid with NGF-potentiating Activity from Verbena littoralis
- Application of Physiologically Active Substances Isolated from Natural Resources to Pharmacological Studies
- Studies on the Constituents of Actinostemma lobatum MAXIM. II. : Structures of Actinostemmosides G and H, New Dammarane Triterpene Glycosides Isolated from the Herb(Organic,Chemical)
- Tareciliosides H—M: Further Cycloartane Glycosides from Leaves of Tarenna gracilipes
- Imaging of Ca^ Release by Caffeine and 9-Methyl-7-bromoeudistomin D and the Associated Activation of Large Conductance Ca^ -Dependent K^+ Channels in Urinary Bladder Smooth Muscle Cells of the Guinea Pig
- Sesquiterpene Esters from the Fruits of Celastrus orbiculatus
- 5-Alkylresorcinol glucosides from the leaves of Grevillea robusta Allan Cunningham
- Megastigmane glucosides and an unusual monoterpene from the leaves of Cananga odorata var. odorata, and absolute structures of megastigmane glucosides isolated from C. odorata var. odorata and Breynia officinalis
- Elaeocarpionoside, a megastigmane glucoside from the leaves of Elaeocarpus japonicus Sieb. et Zucc.
- Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii
- Myrseguinosides A—E, Five New Glycosides from the Fruits of Myrsine seguinii
- Honeybee Royal Jelly Stimulates CRE-mediated Transcription in a PKA- but Not MEK/ERK-dependent Manner in PC12D Cells
- Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity
- Proinsulin C-Peptide Stimulates a PKC/IκB/NF-κB Signaling Pathway to Activate COX-2 Gene Transcription in Swiss 3T3 Fibroblasts
- Shishihakuhito, a Kampo Medicine for Atopic Dermatitis, Prevents Lipopolysaccharide-induced Activation of NF-κB-dependent Transcription in C6 Rat Glioma Cells
- Ephedorae herba Decreases Lipopolysaccharide-Induced Cyclooxgenase-2 Protein Expression and NF-κB-Dependent Transcription in C6 Rat Glioma Cells
- Search for Herbal Extracts with the Activity to Stimulate Tyrosine Hydroxylase Gene Transcription in PC12D Cells
- V-1 Enhances PMA-Induced Activation of NF-κB-Dependent Transcription in PC12D cells
- V-1, a Positive Regulator of Tyrosine Hydroxylase Gene Expression, Promotes Maitotoxin- and Palytoxin-induced Norepinephrine Secretion in PC12D Cells
- Screening of Natural Medicines Used in Vietnam for Trypanocidal Activity against Epimastigotes of Trypanosoma cruzi
- Trypanocidal Flavonoids from Sophora flavescens
- Flavonoid Constituents of Dracocephalum kotschyi Growing in Iran and Their Trypanocidal Activity
- Inhibitory Action of Paraguayan Medicinal Plants on 5-Lipoxygenase
- Isolation of Acorane-Type Sesquiterpenes from the Paraguayan Medicinal Plant Elinorus latiflorus Nees(Natural Medicine Note)
- New Benzoxepin Glucoside from Transformed Root Cultures of Helianthus annuus L.
- Gallates of isoorientin and (2S)-1,2-propanediol glucoside from the leaves of Schoepfia jasminodora
- Phenolics in Tissue Cultures of Scutellaria
- A glycerol α-D-glucuronide and a megastigmane glycoside from the leaves of Guettarda speciosa L.
- Flavonol glycosides from the leaves of Indigofera zollingeriana
- Prenylated flavonoid glucoside and two aliphatic alcohol glycosides from the leaves of Euodia meliaefolia (Hance) Benth
- New iridoid diesters of glucopyranose from Linaria canadensis (L.) Dum.
- Medicinal plants of Thailand (2) chemical studies on the seed kernels of Entada rheedei Sprengel
- Inhibitory Effects of Citrus Polymethoxyflavones, Nobiletin and its Analogues, on Acetylcholinesterase Activity