The Behavior of Dihydropyrazine with DNA Strand-Breakage Activity in Vivo(Biochemistry/Molecular Biology)

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概要

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• The effects on the viability of cell lines treated with 2,3-dihydro-5,6-dimethylpyrazine and its derivatives, which revealed DNA strand-breakage activity by the generation of radicals in vitro, were recognized from certain morphological changes and the detection of apoptosis-related proteins: cleaved PARP and SAPKIJNK. These results would suggest that sugar-derived dihydropyrazines induce changes in the cells of certain organs and cause various internal injuries in vivo. The biodistribution of ^<14>C-labelled 2,3-dihydro-5,6-dimethylpyrazine was studied in mouse and the autoradiograms showed highly contrasting results. Radioactivity was high in the brain, spinal cord, salivary gland, and thymus and low in the heart, stomach, and blood. The result was supported by the activity (% dose per organ).

• 公益社団法人日本薬学会の論文
• 2003-11-01

著者

• Yamaguchi Toshiaki

  Kissei Pharmaceutical Co. Ltd. Central Research Laboratories

• Yamaguchi Takuji

  Central Research Laboratory Tsumura & Co.

• Matsunaga Keiji

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Takata Jiro

  Laboratory Of Drug Design And Drug Delivery Faculty Of Pharmaceutical Sciences Fukuoka University

• ITO Shigeru

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• YAMAGUCHI Tadatoshi

  Department of Hygiene, Miyazaki Medical College

• MATSUNAGA Kazuhisa

  Faculty of Pharmaceutical Sciences, Fukuoka University

• TAKATA Jiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• KARUBE Yoshiharu

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Karube Yoshiharu

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Matsunaga Kazuhisa

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Ito S

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• YOSHIDA Keisuke

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Yamaguchi T

  Tsumura Res. Laboratories Tsumura & Co.

• Matsunaga K

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Takata Jiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• NOMURA Hajime

  Department of Laboratory Medicine, Miyazaki Medical College

• Nomura H

  Department Of Laboratory Medicine Miyazaki Medical College

• Nomura Hajime

  Department Of Anesthesiology Hyogo College Of Medicine

• Ito Shigeru

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• Mihashi Kunihide

  Faculty Of Pharmaceutical Sciences Fukuoka University

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