The Powerful Stimulatory Action of 6-O-Acetyl-9-methyl-7-bromoeudistomin D on the Contractile Protein System of Rabbit Skeletal Muscle
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概要
- 論文の詳細を見る
6-O-Acetyl-9-methyl-7-bromoeudistomin D (AMBED) (>10-6 M), a derivative of eudistomin D, markedly enhanced the superprecipitation and the ATPase activity of skeletal muscle myosin B. In both the superprecipitation and ATPase activity of myosin B, the concentration-response curve for Ca2+ was shifted upwards by AMBED. AMBED did not affect the Ca2+-, K+-EDTA- or Mg2+-ATPase of myosin or the ATPase of actomyosin reconstituted from actin and myosin. These results suggest that AMBED causes an increase in the actomyosin ATPase activity mediated through the elevation of the maximum response to Ca2+, resulting in enhancement of the superprecipitation of skeletal muscle myosin B.
- 社団法人 日本薬理学会の論文
著者
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Matsunaga Keiji
Graduate School Of Pharmaceutical Sciences Kyoto University
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OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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MATSUNAGA Kimihiro
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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Matsunaga K
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga Kimihiro
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences
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NAKATANI Keigo
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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Nakatani Keigo
Department Of Pediatrics National Defense Medical College
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Nakatani Keigo
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Kobayashi J
Sapporo Breweries Ltd. Shizuoka Jpn
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Matsunaga Kimihiro
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Mihashi Kunihide
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kobayashi Jun'ichi
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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Kobayashi Jun'ichi
Department Of Pharmacognosy Faculty Of Phamarceutical Sciences Hokkaido University
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Nakatani Keigo
Department of Electrical Engineering, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
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