Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on Intracellular Ca^<2+> Mobilization in C6 Rat Glioma Cells
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概要
- 論文の詳細を見る
Glial cells are able to support neurons physically and functionally. The present study was undertaken to determine the effects of Kampo medicines on glial cell function, especially Ca<2+> mobilization. C6 rat glioma cells expressed H_1-histamine, muscarinic cholinergic and adrenergic α_1-receptors, simulation of which resulted in phosphoinositive hydrolysis and increase in intracellular Ca<2+> concentration ([Ca<2+>]_i).The water extracts of Sho-saiko-to and San'o-shashin-to, Kampo medicines which contain Scutellariae Radix (Ogon, the root of Scutellaria baicalensis GEORI), inhibited histamine (100μM)-induced increase in [Ca<2+>]_i in a concentration-dependent manner. The water extract of Scutellariae Radix potently decreased [Ca<2+>]_i in a concentration-dependent manner. Sho-saiko-to, San'o-shashin-to and Scutellariae Radix significantly inhibited histamine-induced accumulation of total [^3H]inositol phosphates, consistent with their inbition of the increase in [Ca<2+>]_i. These results suggest that Sho-saiko-to, San'o-shashin-to and Scutellariae Radix inhibit Ca<2+> mobilization mediated via an inhibition of phospholipase C. The inhibitory effect may be important in interpreting the pharmacological actions of above Kampo medicines.
- 公益社団法人日本薬学会の論文
- 1998-10-15
著者
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OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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SAKAKIBARA Iwao
Tsumura and Co., Pharmacology Research Department, R&D Division
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Nakahata Norimichi
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Jap
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KUBO Masayoshi
Tsumura Central Research Laboratories, Tsumura and Co.
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Kubo Masayoshi
Kampo And Pharmacognosy Laboratory Tsumura And Co.
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OHIZUMI Yasushi
Graduate School of Pharmaceutical Sciences, Tohoku University
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KYO Reiki
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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Yasushi Ohizumi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Kubo Masayoshi
Tsumura Central Research Laboratories Tsumura And Co.
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Kubo M
Kampo And Pharmacognosy Laboratory Tsumura And Co.
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Nakahata N
Department Of Cellular Signaling Graduate School Of Pharmaceutical Sciences Tohoku University
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Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
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Nakahata Norimichi
Inst. For International Advanced Res. And Education Tohoku Univ. International Advanced Res. And Edu
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Sakakibara Iwao
Tsumura & Co.
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Sakakibara Iwao
Tsumura Central Research Laboratories Tsumura And Co.
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Kyo Reiki
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Kubo M
Tsumura And Co.
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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