EFFECTS OF FLUVOXAMINE ON BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA IN ALZHEIMER'S DISEASE : A REPORT OF THREE CASES
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概要
- 論文の詳細を見る
OBJECTIVE : To report 3 cases of severe behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) with fluvoxamine treatment and to discuss the treatment implications for use of the drug.CASE SUMMARY: An 83-year-old woman was diagnosed with AD. Before treatment, she showed sudden irritation and excitement. Her BEHAVE-AD score was 40. She was started on fluvoxamine and quetiapine. Eight weeks later, she was friendly and thankful towards the staff. Her BEHAVE-AD score was 10. The second case was a 79-year-old woman diagnosed with AD. Before treatment, she attempted to leave our hospital and wandered and shouted throughout the day. Her BEHAVE-AD score was 42. She was started on fluvoxamine, and the dosage was gradually increased. Eight weeks later, the shouting and excitement disappeared almost completely. Her BEHAVE-AD score was 13. The third case was a 79-year-old man diagnosed with AD. Before treatment, we put him in a private, locked room because he was extremely agitated and violent because of delusions. His BEHAVE-AD score was 42. He was started on fluvoxamine and sodium valproate. Eight weeks later, the delusion became mild and did not affect his mood or behavior. His BEHAVE-AD score at this point was 4.DISCUSSION : Fluvoxamine was effective in controlling BPSD with AD. This finding shows that the pathophysiology of BPSD due to AD may occur because of a hyposerotonergic state in the brain.CONCLUSION : These cases show that fluvoxamine appears to be effective in the control of BPSD with AD.
- 福島医学会の論文
著者
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Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
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Ohtomo Koji
Department Of Molecular Pathology The Research Institute Of Tuberculosis Japan Anti-tuberculosis Ass
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Shirakawa Hisayoshi
Department Of Neuropsychiatry School Of Medicine Fukushima Medical University Fukushima Japan
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Mashiko Hirobumi
Department Of Neuropsychiatry Fukushima Medical University School Of Medicine
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SATO TADAHIRO
Kotokukai Sato Hospital
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KURITA MASATAKE
Kotokukai Sato Hospital
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NISHINO SATOSHI
Kotokukai Sato Hospital
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SHIN-ICHI NIWA
Department of Neuropsychiatry, Fukushima Medical University School of Medicine
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SHIRAKAWA HISAYOSHI
Department of Neuropsychiatry, Fukushima Medical University School of Medicine
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