Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
スポンサーリンク
概要
- 論文の詳細を見る
There are several Kampo medicines (Chinese herbal medicines) containing both Bupleuri Radix and Scutellariae Radix, which are used for the treatment of inflammation. Saikosaponins are derived from Bupleuri Radix, and baicalein is from Scutellariae Radix. The present study was undertaken to investigate the pharmacological interaction of saikosaponin b1 and baicalein in prostaglandin E_2 (PGE_2) release from C6 rat glioma cells in vitro. Saikosaponin a, b1 and d potently stimulated PGE_2 release, while saikosaponin b2 and c moderately stimulated PGE_2 release. Saikosaponin b1 caused an irreversible elevation of intracellular Ca^<2+> concentration, which was eliminated by removing extracellular Ca^<2+>. On the other hand, baicalein inhibited saikosaponin b1-induced PGE_2 release in a concentration-dependent manner. These results suggest that saikosaponins are activators of PGE_2 release, and baicalein is one of the functional inhibitors of PGE_2 release by saikosaponins.
- 公益社団法人日本薬学会の論文
- 1999-12-15
著者
-
Nakai Yoichiro
Kampo And Pharmacognosy Laboratory Tsumura And Co.
-
Nakai Yoichiro
東北大学 薬研究 分子生物薬
-
OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
-
Nakahata Norimichi
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Jap
-
Kubo Masayoshi
Kampo And Pharmacognosy Laboratory Tsumura And Co.
-
Kubo Masayoshi
Kampo & Pharmacognosy Laboratory Tsumura & Co
-
OHIZUMI Yasushi
Graduate School of Pharmaceutical Sciences, Tohoku University
-
KYO Reiki
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
-
KODAMA Yasuo
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
-
Yasushi Ohizumi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Kubo M
Kampo And Pharmacognosy Laboratory Tsumura And Co.
-
Kodama Yasuo
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Nakahata N
Department Of Cellular Signaling Graduate School Of Pharmaceutical Sciences Tohoku University
-
Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
-
Nakahata Norimichi
Inst. For International Advanced Res. And Education Tohoku Univ. International Advanced Res. And Edu
-
Kyo Reiki
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
-
Kubo M
Tsumura And Co.
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
-
Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
-
Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
関連論文
- Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, inhibits IgE-mediated histamine release from rat RBL-2H3 basophilic leukocyte cells
- P-469 ANTI-ALLERGIC AND ANTI-INFLAMMATORY ACTIVITIES OF 1'S-1'-ACETOXYCHAVICOL ACETATE AND RELATED COMPOUNDS
- Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang
- Anti-allergic Effects of Cnidii Monnieri Fructus (Dried Fruits of Cnidium monnieri) and Its Major Component, Osthol
- Study on Anti-Oketsu Activity of Rhubarb II. Anti-allergic Effects of Stillbene Components from Rhei undulati Rhizoma(Dried Rhizome of Rheum undulatum Cultivated in Korea)
- Studies on Alismatis Rhizoma. III. Stereostructures of New Protostane-Type Triterpenes, Alisols H, I, J-23-Acetate, K-23-Acetate, L-23-Acetate, M-23-Acetate, and N-23-Acetate, from the Dried Rhizome of Alisma orientale
- Studies on Alismatis Rhizoma. II. Anti-complementary Activities of Methanol Extract and Terpene Components from Alismatis Rhizoma (Dried Rhizome of Alisma orientale)
- Inhibitory Effects of Dehydrocorydaline Isolated from Corydalis Tuber against Type I-IV Allergic Models
- Anti-inflammatory Activities of 70% Methanolic Extract from Cinnamomi Cortex
- Studies on Palauan Medicinal Herbs II : Activation of Mouse Macrophages RAW 264.7 by Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL. and Its Acylglucosylsterols(Pharmacognosy)
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Umberiferae Plant Extracts and Their Coumarin Constituents(Pharmacognosy)
- Anti-proliferative effect of Ginseng Radix on human premyelocytic leukemia cells (HL-60)
- α-Mangostin Induces Ca^-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
- Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones(Pharmacognosy)
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents(Pharmacognosy)
- Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum)I. : Active Constituents Inhibiting Testosterone 5α-Reductase
- Antipruritic Effect of Cnidii Monnieri Fructus : (Fruits of Cnidium monnieri Cusson)
- Testosterone 5α-Reductase Inhibitory Active Constituents from Anemarrhenae Rhizoma
- Anti-androgenic Activity of Myricae Cortex-Isolation of Active Constituents from Bark of Myrica rubra
- Metabolic Fate of Ulinastatin (2); Pharmacokinetics in Rabbits Following Intra-Articular Administration
- PHARMACOKINETIC STUDY OF ULINASTATIN AFTER INTRA-ARTICULAR ADMINISTRATION TO RABBITS
- Search for Constituents with Neurotrophic Factor-Potentiating Activity from the Medicinal Plants of Paraguay and Thailand
- Changes in pH Increase Perfusion Pressure of Coronary Arteries in the Rat
- The Mechanism of Rabbit Platelet Aggregation Induced by 2,5-Di-(tert-butyl)-1,4-benzohydroquinone, an Inhibitor of Endoplasmic Reticulum Ca^-ATPase
- The Mode of Inhibitory Action of α-Mangostin, a Novel Inhibitor, on the Sarcoplasmic Reticulum Ca^-Pumping ATPase from Rabbit Skeletal Muscle
- Two New Monoterpene Peroxide Glycosides from Aster scaber
- Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
- Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice
- Inhibitory Effect of Ethanol Extract of Piper longum L. on Rabbit Platelet Aggregation through Antagonizing Thromboxane A_2 Receptor(Pharmacology)
- Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on Intracellular Ca^ Mobilization in C6 Rat Glioma Cells
- The Uterus Sustains Stable Biological Clock during Pregnancy
- Effect of Pore Size on the Gaseous Adsorption of Ethenzamide on Porous Crystalline Cellulose and the Physicochemical Stability of Ethenzamide after Storage
- Freeze-Drying of Drug-Oligosaccharide Binary System
- Determination of Solubility Parameters for Solid Medicinals and Excipients
- STUDY OF FREEZE-DRYING IN DRUG-ADDITIVE BINARY SYSTEM
- POSSIBLE MECHANISM BEHIND THE INTERACTIONS BETWEEN POROUS POWDER AND CRYSTALLINE MEDICINALS
- Inhibitions of Histamine Release and Prostaglandin E_2 Synthesis by Mangosteen, a Thai Medicinal Plant
- THROMBOXANE A_2 RECEPTORS IN RABBIT CULTURED ASTROCYTES
- Nardosinone Enhances Nerve Growth Factor-Induced Neurite Outgrowth in a Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Manner in PC12D Cells
- Nerve Growth Factor-Potentiating Compounds from Picrorhizae Rhizoma
- Enhancement of the Nerve Growth Factor-Mediated Neurite Outgrowth from PC12D Cells by Chinese and Paraguayan Medicinal Plants
- The Powerful Stimulatory Action of 6-O-Acetyl-9-methyl-7-bromoeudistomin D on the Contractile Protein System of Rabbit Skeletal Muscle
- Inhibitory Effect of Mao-Bushi-Saishin-to on Prostaglandin E_2 Synthesis in C6 Rat Glioma Cells(Pharmacology)
- Ephedrae herba in Mao-Bushi-Saishin-To Inhibits IgE-Mediated Histamine Release and Increases cAMP Content in RBL-2H3 Cells
- Inhibition of Microtubule Polymerization by SK&F 96365, a Blocker of Receptor-Linked Ca^ Entry
- Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells(Pharmacology)
- Littorachalcone, a New Enhancer of NGF-Mediated Neurite Outgrowth, from Verbena littoralis
- Structure Activity Relationship and Molecular Modeling Analysis of Nantenine Derivatives in 5-HT_ and α_ Receptor Antagonistic Activities
- Constituents of a Paraguayan Medicinal Plant Verbena littoralis H. B. K.
- The Combination of Rat Mast Cell and Rabbit Aortic Smooth Muscle Is the Simple Bioassay for the Screening of Anti-allergic Ingreditent from Methanolic Extract of Corydalis Tuber(Pharmacognosy)
- Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes
- Alteration of Adenylyl Cyclase Type 6 Expression in Human Astrocytoma Cells After Exposure to Simulated Microgravity
- Physiological Significance of Thromboxane A_2 Receptor Dimerization
- Different Pathways for Activation of Extracellular Signal-Regulated Kinase through Thromboxane A_2 Receptor Isoforms(Pharmacology)
- Ephedrae herba (Mao) decreased histamine content in RBL-2H3 cells
- Clerodane Diterpenoids and Flavonoids with NGF-Potentiating Activity from the Aerial Parts of Baccharis gaudichaudiana
- Xanthones with NGF-potentiating activity
- Prenylated Xanthones from Garcinia xanthochymus
- A New Iridoid Glycoside with Nerve Growth Factor-Potentiating Activity, Gelsemiol 6'-trans-Caffeoyl-1-glucoside, from Verbena littoralis
- Identification of Rosmarinic Acid as a Novel Antidepressive Substance in the Leaves of Perilla frutescens Britton var.acuta Kudo (Perillae Herba)
- Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells(Pharmacology)
- Iridoids and Sesquiterpenoids with NGF-Potentiating Activity from the Rhizomes and Roots of Valeriana fauriei
- Flavonoid Glycosides from Cecropia adenopus
- Naphthoquinone and Iridoid with NGF-potentiating Activity from Verbena littoralis
- Application of Physiologically Active Substances Isolated from Natural Resources to Pharmacological Studies
- Imaging of Ca^ Release by Caffeine and 9-Methyl-7-bromoeudistomin D and the Associated Activation of Large Conductance Ca^ -Dependent K^+ Channels in Urinary Bladder Smooth Muscle Cells of the Guinea Pig
- Involvement of Adenosine A_ Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine
- Sesquiterpene Esters from the Fruits of Celastrus orbiculatus
- Potent Antioxidative Activity of Unripe Fruits of Garcinia mangostana L
- Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity
- Physiological and Subjective Responses to Standing Showers, Sitting Showers, and Sink Baths
- Physiological and subjective responses to standing showers, sitting showers, and sink baths
- Proinsulin C-Peptide Stimulates a PKC/IκB/NF-κB Signaling Pathway to Activate COX-2 Gene Transcription in Swiss 3T3 Fibroblasts
- Shishihakuhito, a Kampo Medicine for Atopic Dermatitis, Prevents Lipopolysaccharide-induced Activation of NF-κB-dependent Transcription in C6 Rat Glioma Cells
- Ephedorae herba Decreases Lipopolysaccharide-Induced Cyclooxgenase-2 Protein Expression and NF-κB-Dependent Transcription in C6 Rat Glioma Cells
- A COMPARATIVE STUDY ON THE CARDIOTOXICITY OF 5-FLUOROURACIL AND FTORAFUR IN RABBITS
- DEPRESSIVE EFFECT OF EPINEPHRINE MEDIATED VIA ADRENERGIC BETA-RECEPTOR IN ISOLATED RAT COLON AND DUODENUM
- Search for Herbal Extracts with the Activity to Stimulate Tyrosine Hydroxylase Gene Transcription in PC12D Cells
- V-1 Enhances PMA-Induced Activation of NF-κB-Dependent Transcription in PC12D cells
- Inhibitory Effects of Atractylodis Lanceae Rhizoma and Poria on Collagen- or Thromboxane A2-Induced Aggregation in Rabbit Platelets
- Two Distinct Effects of 12S-Hydroxyeicosatetraenoic Acid on Platelet Aggregation by Zooxanthellatoxin-A and Ionomycin
- Maitotoxin-Induced Phosphoinositide Hydrolysis Is Dependent on Extracellular but Not Intracellular Ca^ in Human Astrocytoma Cells
- EFFECTS OF PROSTAGLANDINS ON EXCITATORY TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
- Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis
- Xanthones with NGF-potentiating activity
- Flavonoid Glycosides from Cecropia adenopus
- Studies on Rehmanniae Radix. V. 5-Hydroxymethyl-2-furaldehyde, Active Constituent of the Steamed Root of Rehmannia glutinosa Having Increasing Activity of Erythrocyte Deformability in Rats
- Studies on Palauan Medicinal Herbs. I. : Antidiabetic Effect of Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL.
- Interspecific and Local Variations of Magnolol, Honokiol, and β-eudesmol Contents and Correlation between those Contents and Morphological Characters of Magnolia Barks
- Bioactive Constituent of Notopterygii Rhizoma, Falcarindiol having Antibacterial Activity against Staphylococcus aureus isolated from Patients with Atopic Dermatitis
- Effects of 70% Methanol Extract from Evodiae Fructus (Fruit of Evodia rutaecarpa var. bodinieri) and Its Alkaloidal Components on Blood Circulation
- Anti-allergic Activities of 70% Methanol Extract of Evodiae Fructus (Fruits of Evodia rutaecarpa var. bodinieri) and Its Components
- The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
- Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells
- Isolation, Structural Elucidation, and Neuroprotective Effects of Iridoids from Valeriana jatamansi
- QUALITATIVELY DIFFERENT RESPONSE OF ISOLATED RABBIT AORTA TO METHYLENE BLUE ADMINISTERED FROM INTIMAL AND ADVENTITIAL SURFACE
- EFFECTS OF FLUVOXAMINE ON BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA IN ALZHEIMER'S DISEASE : A REPORT OF THREE CASES
- A COMPARATIVE STUDY ON CONTRACTILE RESPONSES OF RABBIT AND GUINEA PIG VASA DEFERENTIA TO ELECTRICAL FIELD STIMULATION