Two Distinct Effects of 12S-Hydroxyeicosatetraenoic Acid on Platelet Aggregation by Zooxanthellatoxin-A and Ionomycin
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概要
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The marine toxin zooxanthellatoxin-A (ZT-A) and the Ca2+ ionophore ionomycin caused aggregation in rabbit platelets. While ZT-A-induced platelet aggregation was inhibited by indomethacin, ionomycin-induced aggregation was potentiated by the drug. In contrast, both ZT-A- and ionomycininduced accumulations of thromboxane B2 (TXB2), a stable metabolite of thromboxane A2 (TXA2), were completely inhibited by indomethacin. 12S-Hydroxyeicosatetraenoic acid (12-HETE), which could be accumulated in the presence of indomethacin, inhibited ZT-A-induced aggregation, but it potentiated the ionomycin-induced one. These results suggest that the different effects of indomethacin may be attributed to the distinct effects of 12-HETE on ZT-A- and ionomycin-induced platelet aggregations.
- 社団法人 日本薬理学会の論文
著者
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Rho Mun-chual
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Nakahata Norimichi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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