Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells
スポンサーリンク
概要
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To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcriptional activity by RJ was enhanced by nobiletin. U0126, a MEK inhibitor, inhibited CRE-mediated transcription by combining RJ plus nobiletin without affecting transcription by RJ alone. These results suggest that RJ stimulates CRE-mediated transcription via an ERK-independent cascade, whereas the increasing CRE-mediated transcriptional effect by nobiletin is dependent on ERK phosphorylation. Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription.
著者
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Mimaki Yoshihiro
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Murata Kiyoshi
Japan Royal Jelly (jrj) Co. Ltd.
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HITOMI Nobuyuki
Japan Royal Jelly (JRJ) Co. Ltd.
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Sakamoto Masahiro
Department Of Physiology Toho University School Of Medicine
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Fujiwara Hironori
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Kogure Ako
Department of Anti-dementia Functional Food Development, Graduate School of Engineering, Tohoku Univ
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Yamakuni Tohru
Laboratory of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
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Yamaguchi Kikuji
Department of Anti-dementia Functional Food Development, Graduate School of Engineering, Tohoku Univ
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