Stimulation of Sarcoplasmic Reticulum Ca^<2+>-ATPase by Gingerol Analogues
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概要
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We have reported previously that [8]-gingerol increased Ca^<2+>-ATPase activity. ^<1,2)>Here we synthesized gingerol related compounds (AP-004,AP-005 and AP-015) and investigated the effects of gingerols ([6]-gingerol, [8]-gingerol and [10]-gingerol) and the synthesized compounds on the Ca^<2+>-ATPase activity of sarcoplasmic reticulum (SR). The Ca^<2+>-ATPase activity and the Ca^<2+>-pumping activity increased by these compounds in a concentration-dependent manner. It is probable that both the o-methoxyphenol and hydrocarbon chain in the molecule of gingerol analogues are necessary for the activation of the Ca^<2+>-pumping ATPase activity of SR.
- 1996-10-15
著者
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Sasaki Susumu
Department Of Medicine Akashi City Hospital
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Ikemoto Fumihiko
Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Shibusawa K
Tohoku Univ. Sendai Jpn
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Shibusawa Kazuki
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Ishikawa Kiyofumi
Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Sasaki Susumu
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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Sasaki Susumu
Department of Materials Science and Technology, Faculty of Engineering, Niigata University, 8050 Ikarashi 2 no-cho, Niigata-shi, Niigata 950-2181, Japan
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ISHIKAWA Kiyofumi
Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.,
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Sasaki Susumu
Department of Atomic Science and Nuclear Engineering Faculty of Engineering, Hokkaido University
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