Renal Denervation Inhibits Hypothalamo-Sympathetic Nerve System in Normotensive and Hypertensive Rats : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

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概要

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• The role of the renal nerve in influencing the hypothalamo-sympathetic nerve system to regulate the cardiovascular system was studied in normotensive Wistar and spontaneously hypertensive rats (SHR). Renal denervation attenuated pressor and sympathetic nerve responses to electrical stimulation of the hypothalamus without lowering the basal blood pressure at 48 hours after denervated operation. These findings suggest that renal denervation could inhibit the hypothalamo-sympathetic nerve system in normotensive rats. The development of hypertension in SHR was completely inhibited by renal denervation during 2 weeks of observation (from 7 to 9 weeks of age) without increasing water intake and urine volume. Pressor responses to intravenous injection of norepinephrine were not affected by renal denervation. The results show that the antihypertensive effect of renal denervation was not due to the changing of vascular reactivity. Pressor and sympathetic nerve responses to hypothalamic stimulation were strongly diminished in renal denervated rats. These results suggest that renal denervation strongly inhibited they hypothalamo-sympathetic nerve system. It is also suggested that the renal afferent nerve may facilitate the hypothlamo-sympathetic nerve system in regulating blood pressure and that this facilitation may contribute to the development of hypertension in SHR.

• 社団法人日本循環器学会の論文
• 1985-09-20

著者

• Okajima Hiroshi

  Department Of Anatomy Kyoto Prefectural University Of Medicine

• IJICHI Hamao

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Yoshimura Manabu

  Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine

• Yoshimura Manabu

  Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine

• Ijichi H

  2nd Department Of Medicine Kyoto Prefectural University Of Medicine

• Iyoda Isao

  Kyoto Prefectural University Of Medicine The Second Department Of Medicine

• Takeda K

  Kyoto Industrial Health Association

• SASAKI Susumu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• LEE Li-chik

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• YOSHIMURA Manabu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• OKAJIMA HIROSHI

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• YOSHIGA MASAHIRO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• IYODA ISAO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TAKAHASHI HAKUO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• Sasaki Susumu

  Department Of Medicine Akashi City Hospital

• Ikegaki Iwao

  Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine

• Takahashi Hakuo

  The Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Lee Li-chik

  The 2nd Depertment Of Internal Medicine Kyoto Prefectural University Of Medicine

• Okabayashi Hideoki

  2nd Department Of Medicine Kyoto Prefectural University Of Medicine

• Okamura H

  Department Of Anatomy Kyoto Prefectural University Of Medicine

• Okamura Hiro-oki

  Department Of Audio-vestibular Neuroscience Tokyo Medical And Dental University

• Sasaki Susumu

  Division Of Hypertension And Nephrology Department Of Medicine Kyoto Prefectural University School O

• Sasaki Susumu

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Okamura Hiro-oki

  Department Of Otolaryngology Tokyo Medical And Dental University

• Ijichi Hamao

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• YOSHIMURA MANABU

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• TAKAHASHI Hakuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Okajima Hiroshi

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

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