Effect of sodium loading and depletion on cyclic nucleotides in plasma and aorta. Interaction between prostacyclin and cyclic nucleotides.
スポンサーリンク
概要
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The present study evaluated the effect of sodium loading and sodium depletion on cAMP and cGMP content of rat aorta. Enhanced generation of prostacyclin (PGI<SUB>2</SUB>) in aorta was noticed in sodium loading and sodium-depletion. As PGI<SUB>2</SUB> is potent vasoactive agent, the interaction between PGI<SUB>2</SUB> generation in the aorta and cyclic nucleotide accumulation in the aorta was investigated. Sodium depletion of rats induced the elevation of both cAMP and cGMP in the aorta and of cAMP in plasma. No change in cyclic nucleotides was noticed following sodium loading. These changes in cyclic nucleotides were felt to reflect the fluctuation of vasoactive agents under various sodium metabolism conditions. These observations may indicate that PGI<SUB>2</SUB> is not a major factor in the regulation of cyclic nucleotide metabolism under sodium loading and sodium depletion. The increased accumulation of cAMP and cGMP in rat aorta in sodium depletion may be due to the cumulative effects of PGI<SUB>2</SUB>, catecholamine and probably angiotension II which are induced by sodium depletion.
著者
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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TAKEDA Kazuo
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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YOSHIMURA Manabu
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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TAKAHASHI HAKUO
Second Department of Medicine, Kyoto Prefectural University of Medicine
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Kitani Teruo
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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HACHIYA TAKASHI
Second Department of Surgery, Hamamatsu University School of Medicine
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KAJITA YOSHIHIRO
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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MIYAZAKI TADAYOSHI
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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OCHI YUKIO
Second Department of Internal Medicine Shiga University of Medical Science
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Ijichi Hamao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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KITANI TERUO
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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YOSHIMURA MANABU
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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TAKAHASHI Hakuo
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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KAJITA YOSHIHIRO
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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TAKEDA Kazuo
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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HACHIYA TAKASHI
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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