The Role of Brain Angiotensin II in the Mechanism of the Pressor Responses to Intracisternal Injection of Hypertonic NaCl in Urethane Anesthetized Rats : THE 11th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
スポンサーリンク
概要
- 論文の詳細を見る
Intracisternal injections of hypertonic NaCl elicited the pressor responses in urethane anesthetized spontaneously hypertensive and normotensive Wistar rats. The intracisternal pretreatment of 1-Sar-8-Ile-angiotensin II, angiotensin II analog, could abolish the pressor responses to intracisternal injections of 5% NaCl in urethane anesthetized spontaneously hypertensive rats, while basal blood pressure was not affected by these pretreatrnent. Both intracisternal and intravenous administration of captopril, an angiotensin I converting enzyme inhibitor, did not alter the pressor effect of hypertonic NaCl in normotensive rats. Basal blood pressure was lowered by intravenous injection of captopril. The involvement of angiotensin II in the pressor mechanism of hypertonic NaCl was confirmed by the enhanced pressor responses to intracisternal injections of 5% NaCl in urethane anesthetized rats pretreated intracisternally with angiotensin II. These findings suggest that angiotensin II itself could play an important role in the pressor responses to intracisternal injections of hypertonic NaCl without involving a converting enzyme system.
- 社団法人日本循環器学会の論文
- 1982-05-20
著者
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Inoue Atsushi
The 2nd Depertment Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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IJICHI Hamao
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Ijichi Hamao
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Takeda K
Kyoto Industrial Health Association
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INOUE Atsushi
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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TAKEDA Kazuo
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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YOSHIMURA Manabu
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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TAKAHASHI HAKUO
Second Department of Medicine, Kyoto Prefectural University of Medicine
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Takahashi Hakuo
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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SHIKUMA RIEKO
Second Department of Internal Medicine Kyoto Prefectural University of Medicine
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TAKASHINA RYOSAKU
Second Department of Internal Medicine Kyoto Prefectural University of Medicine
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Ashizawa Hiroshi
Second Department of Medicine, Kyoto Prefectural University of Medicine
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ASHIZAWA HIROSHI
The Second Department of Medicine, Kyoto Prefectural University of Medicine
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Ashizawa Hiroshi
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine And The Third Department Of Internal Medicine Kyoto P
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Takashina R
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Ijichi Hamao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural Medical College
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YOSHIMURA MANABU
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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TAKAHASHI Hakuo
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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TAKEDA Kazuo
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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ASHIZAWA Hiroshi
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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