INFLUENCE OF ENDOTHELIN ON HUMAN PLATELET AGGREGATION AND PROSTACYCLIN GENERATION FROM HUMAN VASCULAR ENDOTHELIAL CELLS IN CULTURE

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概要

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• The effects of endothelin (ET) on the function of cultured human umbilical vein endothelial cells (HUVEC) and that of human platelets were investigated with reference to endothelium-derived relaxing factor (EDRF) and PGI_2. Considering the platelets, ET had no effect on platelet-rich plasma (PRP) aggregation, the generation of thromboxane A_2 ([TXA_2]) from platelets, and cytosolic free calcium ion concentration ([Ca^<++>]_i), cAMP content ([cAMP]_i) or cGMP con-tent ([cGMP]_i) in platelets. In contrast, the addition of the solution in which HUVEC had been incubated with ET to PRP produced a decrease in PRP aggregation, [TXA_2], and [Ca^<++>]_i, and an increase not only in [cAMP]_i but also in [cGMP]_i in platelets. In the HUVEC pretreated with acetylsalicylic acid (aspirin), this increase of [cGMP]_i Was not affected, but the HUVEC-mediated decrease in PRP aggregation, [TXA_2], and [Ca^<++>]_i induced by ET were not completely abolished. However, the pretreatment of HUVEC with a combination of aspirin and L-NG-monomethyl arginine (LNMMA) as an inhibitor of EDRF completely abolished the HUVEC-mediated decrease in PRP aggregation, [TXA_2] and [Ca^<++>]_i induced by ET, and also abolished the enhancement of [cGMP]_i and [cAMP]_i in platelets. The PGI_2 Of HUVEC was enhanced by ET with no changes in [Ca^<++>]_i, [cAMP]_i and [cGMP]_i. The ET-induced enhancement was remarkably attenuated by pretreating the HUVEC with aspirin, but not with LNMMA. We conclude that ET attenuates the aggregation of platelets through a decrease in [TXA_2] by an increase in [cAMP]_i Via the increase in PGI_2 Of HUVEC, and by an increase in [cGMP]_i Via EDRF.

• 社団法人日本循環器学会の論文
• 1992-05-20

著者

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  京都府立医科大学 内科学第2

• Nakagawa Masao

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Tsuji Hajime

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Sawada Shohei

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• Tamagaki Toshiyuki

  Saiseikai Siga Hospital

• KATO KAZUHARU

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TOYODA TAKEO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• KOBAYASHI KYOICHIRO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• SHIRAI KAORU

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• YAMAMOTO KATSUMI

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TAMAGAKI TOSHIYUKI

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• YAMAGAMI MASAHITO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• YONEDA MITSURU

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TAKADA OSAMU

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• UNO MASASHI

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• Sawada Shigeo

  Faculty Of Science And Technology Kinki University

• Uno Masashi

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Toyoda Takeo

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Shirai Kaoru

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Takada Osamu

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Sawada Susumu

  First Department Of Internal Medicine Tokyo University

• Sawada S

  Saiseikai Shiga Hospital

• Sawada Shohei

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Kato Kazuharu

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Tamagaki Toshiyuki

  The Department Of Internal Medicine Saiseikai Shiga Hospital Imperial Gift Foundation Inc

• Yoneda Mitsuru

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Kobayashi Kyoichiro

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Yamagami Masahito

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Yamamoto Katsumi

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural Medical College

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