THE β-ADRENERGIC RECEPTOR/ADENYLATE CYCLASE SYSTEM IN THE CARDIAC VENTRICLES OF A HYPERTROPHIC CARDIOMYOPATHY RAT MODEL
スポンサーリンク
概要
- 論文の詳細を見る
The WKY/NCrj rat strain is considered to be a good animal model for hypertrophic cardiomyopathy (HCM). The purpose of this study was to examine the β-adrenergic receptor/adenylate cyclase system in the cardiac ventricles of these rats. β-adrenergic receptor density (Bmax) in the right ventricle (RV) was higher in WKY/NCrj than in Wistar rats. In contrast, Bmax in the inter-ventricular septum (IVS) was lower in WKY/NCrj than in Wistar rats. Isoproterenol-stimulated adenylate cyclase activity in cardiac ventricular slices showed that changes corresponded to the changes of Bmax in every type of studied cardiac ventricle. The intracellular adenylate cyclase pathway (GTP γ S-, NaF- and forskolin-stimulated adenylate cyclase activity in cardiac ventricular particulate fraction) did not differ between WKY/NCrj and Wistar rats in any region of the cardiac ventricles. Catecholamine levels tended to be low in the RV and to increase in the IVS of WKY/NCrj rats. Our results suggest that the activity of the β-adrenergic receptor/adenylate cyclase system varies in different cardiac ventricles of the WKY/NCrj rat model for HCM.
- 社団法人日本循環器学会の論文
- 1992-04-20
著者
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Kuribayashi Toshiro
Kuribayashi Clinic of Cardiology
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Katsume Hiroshi
Second department of medicine, Kyoto Prefectural University of Medicine
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Kunishige Hiroshi
Matsushita Memorial Hospital
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Katsume Hiroshi
The 2nd Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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Katsume Hiroshi
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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YAMAMOTO SHINICHI
Second Department of Medicine, Kyoto Prefectural University of Medicine
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KURIBAYASHI TOSHIRO
Department of Anatomy, Kyoto Prefectural University of Medicine
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HASHIMOTO TSUNEICHI
Department of Pharmacology, Kyoto Prefectural University of Medicine
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Hashimoto Tsuneichi
Department Of Pharmacology Kyoto Prefectural University Of Medicine
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Katsume Hiroshi
The 2nd Dept. Of Med. Kyoto Pref. Univ. Of Med.
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Kuribayashi Toshiro
Second Department Of Medicine Kyoto Prefectural University Of Medicine.
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Katahira Toshio
Kuribayashi Clinic Of Cardiology
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Kuribayashi Toshiro
The Second Dept. Of Anat. Kyoto Pref. Univ. Of Med
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Kuribayashi Toshiro
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Kunishige Hiroshi
Kyoto Pref. Hosp. Of Yosa No Umi Kyoto Pref. Univ. Of Med. 2nd Intern. Med.
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Yamamoto Shinichi
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural Medical College
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Kunishige Hiroshi
2nd Dept. Of Intern. Med. Kyoto Pref. Univ. Of Med.
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KATSUME Hiroshi
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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