Hypotension and Hypothalamic Depression Produced by Intracerebroventricular Injections of GABA in Spontaneously Hypertensive Rats : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
スポンサーリンク
概要
- 論文の詳細を見る
To determine the central effects of 4-Amino-n-butyric acid (GABA), pressor and sympathetic nerve responses to electrical stimulation of the ventromedial hypothalamus were recorded following the intracerebroventricular (ICV) injection of GABA. In normotensive Wistar rats, anesthetized with urethane, ICV injections of GABA (50-200 μg) reduced sympathetic nerve activity, arterial blood pressure, and heart rate in a dose-dependent manner. Graded electrical stimulation of the ventromedial hypothalamus (50, 100, 150 μA) increased not only mean blood pressure but also the rate of sympathetic nerve firing, and both responses were attenuated by GABA pretreatment (100, 200 μg,ICV). In spontaneously hypertensive rats (SHR), ICV-injected GABA also reduced sympathetic and cardiovascular activity, but the magnitude of depressor responses was significantly larger in SHR than in normotensive Wister Kyoto controls (WKY). Pressor and sympathetic nerve responses elicited by ventromedial hypothalamic stimulation were initially larger in SHR than in WKY, but upon subsequent ICV injection of GABA, hypothalamic responsiveness in SHR was inhibited more prominently and became comparable to that in WKY. These results suggest that by depressing hypothalamic function, centrally injected GABA decreases sympathetic nerve activity to thereby lower blood pressure and heart rate, and in SHR, ICV-injected GABA reversed hypothalamo-sympathetic hyperactivity and thus attenuated hypertension.
- 社団法人日本循環器学会の論文
- 1986-11-20
著者
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Inoue Atsushi
The 2nd Depertment Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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IJICHI Hamao
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine
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Ijichi H
2nd Department Of Medicine Kyoto Prefectural University Of Medicine
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Iyoda Isao
Kyoto Prefectural University Of Medicine The Second Department Of Medicine
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Takeda K
Kyoto Industrial Health Association
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SASAKI Susumu
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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LEE Li-chik
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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NAKAMURA Yutaka
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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IYOTA Isao
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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FUKUYAMA Masaki
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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INOUE Atsushi
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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TAKEDA Kazuo
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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YOSHIMURA Manabu
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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FUKUYAMA Masaki
Kyoto Prefectural University of Medicine, The Second Department of Medicine
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Sasaki Susumu
Department Of Medicine Akashi City Hospital
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Ikegaki Iwao
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Nakamura Yoshiro
Cardio-pulmonary Division Department Of Medicine Keio University School Of Medicine
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Lee Li-chik
The 2nd Depertment Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakamura Yasuyuki
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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Nakamura Y
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Fukuyama Masaki
Kyoto Prefectural University Of Medicine The Second Department Of Medicine
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Sasaki Susumu
Division Of Hypertension And Nephrology Department Of Medicine Kyoto Prefectural University School O
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Sasaki Susumu
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Ijichi Hamao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural Medical College
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YOSHIMURA MANABU
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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TAKEDA Kazuo
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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