CENTRALLY INHIBITORY EFFECT OF ADRENALLINE ON CARDIOVASCULAR AND SYMPATHETIC NERVE SYSTEM IN URETHANE ANESTHETIZED RAT

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概要

• 論文の詳細を見る

• The present study was undertaken to determine the central effect of adrenaline. Adrenaline was administered to the cisterna magna in urethane anesthetized rats. Following the intracisternal injections, the blood pressure dropped and reached a plateau after 15 min, the hypotensive effect continuing for at least 30 min. The heart rate also showed concomitantly with the depressor effect. The vehicle treated rats did not show any cardiovascular responses. The cardiovascular responses in the experimental rats were accompanied by an inhibition of the sympathetic nerve activity. Pressor responses to electrical stimulation of the posterior hypothalamus were partly inhibited, while pressor responses to intravenous injections of noradrenaline remained unchanged. In DOCA hypertensive rats, the depressor responses to intracisternal injections of adrenaline were augmented. These findings suggest that adrenaline in the brain could contribute to the inhibitory mechanism of the cardiovascular system accompanied by inhibition of the sympathetic nerve system, and that this mechanism may be attenuated in DOCA hypertensive rats.

• 社団法人日本循環器学会の論文
• 1985-03-20

著者

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Okajima Hiroshi

  Department Of Anatomy Kyoto Prefectural University Of Medicine

• IJICHI Hamao

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Yoshimura Manabu

  Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine

• Yoshimura Manabu

  Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine

• Ijichi H

  2nd Department Of Medicine Kyoto Prefectural University Of Medicine

• Iyoda Isao

  Kyoto Prefectural University Of Medicine The Second Department Of Medicine

• Takeda K

  Kyoto Industrial Health Association

• SASAKI Susumu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• YOSHIMURA Manabu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• OKAJIMA HIROSHI

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• IYODA ISAO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TAKAHASHI HAKUO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• Sasaki Susumu

  Department Of Medicine Akashi City Hospital

• Ikegaki Iwao

  Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine

• Takahashi Hakuo

  The Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Okabayashi Hideoki

  2nd Department Of Medicine Kyoto Prefectural University Of Medicine

• Okamura H

  Department Of Anatomy Kyoto Prefectural University Of Medicine

• Okamura Hiro-oki

  Department Of Audio-vestibular Neuroscience Tokyo Medical And Dental University

• Sasaki Susumu

  Division Of Hypertension And Nephrology Department Of Medicine Kyoto Prefectural University School O

• Sasaki Susumu

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Okamura Hiro-oki

  Department Of Otolaryngology Tokyo Medical And Dental University

• Ijichi Hamao

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural Medical College

• YOSHIMURA MANABU

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• TAKAHASHI Hakuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Okajima Hiroshi

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

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