ROLE OF SYMPATHETIC NERVE INHIBITION IN THE VASODEPRESSOR EFFECT OF BROMOCRIPTINE IN NORMOTENSIVE AND HYPERTENSIVE RATS

スポンサーリンク

概要

• 論文の詳細を見る

• This study aimed to elucidate the mechanism of the hypotensive effect of bromocriptine (BRC), and to investigate whether or not the effects of BRC on the sympathetic nervous system are altered in hypertension. BRC was administered intravenously to normotensive and spontaneously hypertensive rats (SHR). It elicited hypotensive effects dose-dependently in urethane-anaesthetized normotensive rats, an effect which was antagonized with metoclopramide. Pretreatment with intravenous hexamethonium attenuated the hypotensive effect of BRC. BRC decreased plasma norepinephrine (NE) without inhibiting the sympathetic nerve spikes recorded from the postganglionic sympathetic nerve bundle. The hypotensive effect of BRC was significantly greater in SHR than in Wistar Kyoto Rats (WKY). Decrease in NE by BRC was also significantly greater in SHR than in WKY. These results suggest that the hypotensive effect of BRC is induced by suppression of NE release, not by inhibition of sympathetic nerve spikes, and that the dopaminergic presynaptic inhibition is attenuated in SHR.

• 社団法人日本循環器学会の論文
• 1992-09-20

著者

• TAKEDA Kazuo

  Kyoto Industrial Health Association

• Itoh Hirosh

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Itoh Hiroshi

  Second Department Of Medicine Asahikawa Medical College

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Tanaka Motoo

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Takeda K

  Kyoto Industrial Health Association

• SASAKI Susumu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• Sasaki Susumu

  Department Of Medicine Akashi City Hospital

• Takesako Toshiyuki

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Nakata Tetsuo

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• OGURO MINAKO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TAKENAKA KEN

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• HIRATA MASAHIRO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TANABE SHINICHI

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• HAYASHI JUNKO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• Oguro Minako

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Hayashi Junko

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Nakata Tetsuo

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Nakamura T

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Tanabe Shinichi

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Hirata Masahiro

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Sasaki Susumu

  Division Of Hypertension And Nephrology Department Of Medicine Kyoto Prefectural University School O

• Sasaki Susumu

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural Medical College

• Nakagawa Tatsuya

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• TANAKA MOTOO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Takenaka Ken

  Second Department of Medicine Kyoto Prefectural University of Medicine

関連論文

• Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications : a sub-analysis of the CASE-J trial
• Papillary Fibroelastoma of the Aortic Valve : Evaluation with Transesophageal Echocardiography and Magnetic Resonance Imaging
• Relationship between Coronary Blood Flow Velocity Waveform and Transmural Distribution of Myocardial Blood Flow in Coronary Artery
• Human Herpes Virus 8-Negative Primary Effusion Lymphoma in a Patient With a Ventriculoperitoneal Shunt Tube
• Flow cytometric analysis of Thy-1 expression in myelodysplastic syndrome
• Flow cytometric analysis of Thy-1 expression in CD34-positive acute leukemia
• Overexpression of PRAD1/cyclin D1 in plasma cell leukemia with t(11;14)(q13;q32)
• Expression of Adhesion Molecules on Myeloma Cells
• DNA Cytofluorometry of Leukemic Cells identified by Wright-Giemsa Stain; Study on Destaining Method
• Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients : Rationale, Design, and Methods
• -423- ATRIAL NATRIURETIC POLYPEPTIDE (ANP) IN MICE WITH EXPERIMENTAL VIRAL MYOCARDITIS : ALTERATION IN ATRIAL, VENTRICULAR AND PLASMA ANP LEVELS
• Magnetic Resonance Imaging Differentiated Partial From Complete Absence of the Left Pericardium in a Case of Leftward Displacement of the Heart
• PE-332 Randomized Evaluation of Atorvastatin in patients with Coronary Heart Disease(Atherosclerosis, Clinical 7 (IHD) : PE57)(Poster Session (English))
• Patients with Isolated Ventricular Noncompaction Previously Diagnosed as Dilated Cardiomyopathy
• 2D-Black Blood Magnetic Resonance Imaging Non-Invasively Detects Coronary Atherosclerosis
• Investigation of Plasma Soluble Form of Fas and Fas-Ligand in Patients with Hypertrophic Cardiomyopathy
• Elevation of Brain Natriutetic Peptide in Pericardia! Fluid in Patients with Postoperative Atrial Fibrillation Undergoing Off-Pump Coronary Artery Bypass Surgery
• Effect of local delivery of docetaxel on rabbit iliac stenosis after balloon injury
• Identification of Left Ventricular Dysfunction by gated SPECT in Angina Patients Despite Normal SPECT Images
• Plasma natriuretic peptides levels in hypertrophic cardiomyopathy with or without left ventricular cavity obliteration
• Evaluation of Atrial Contribution to Left Ventricular Filling by Myocardial Gated SPECT
• Relationship between Plasma Natriuretic Peptides Levels and Coronary Flow Reserve Evaluated by ^Tc-tetrofosmin myocardial SPECT in Patients with Hypertrophic Cardiomyopathy
• Electrocardiographic Score as a Predictor of Mortality After Subarachnoid Hemorrhage
• Early Detection of Orthostatic Hypotension by Quantitative Sudomotor Axon Reflex Test (QSART) in Type 2 Diabetic Patients
• Assessment of Coronary Microcirculation Disturbance in Patients with Coronary Ectasia with ATP Loading Tc-99m-Tetrofosmin Myocardial SPECT
• Effectiveness of Transcatheter Mechanical Thrombus Aspiration in Patients with Acute Coronary Syndrome
• Expression and Function of CD36 on the Human Myocardium
• Increasing myocardial ^I-BMIPP uptake in non-ischemic area in a patient with acute myocardial ischemia
• Hypotension and Hypothalamic Depression Produced by Intracerebroventricular Injections of GABA in Spontaneously Hypertensive Rats : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Salt Elevates Blood Pressure with Biphasic Changes in Hypothalamic Responsiveness : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Surgical Removal of Intra-Aortic Balloon Cathetet With Fractured Nitinol Central Lumen : A Case Report
• Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and ^Tc-tetrofosmin myocardial single photon emission computed tomography
• A patient with type I CD36 deficiency whose myocardium accumulated ^123 I-BMIPP after 4 years
• Apoptotic Myocytes Generate Monocyte Chemoattractant Protein-1 to Draw the Activated Macrophages in Ischemia-Reperfused Rat Hearts
• Aldosterone Activates Calcineurin-Dependent Mitochondrial Apoptotic Pathway in Cultured Rat Cardiac Myocytes
• Amlodipine Inhibits Doxorubicin-lnduced Apoptosis in Neonatal Rat Cardiac Myocytes : Amlodipine Releases Nitric Oxide from Cultured Rat Cardiac Myocytes
• Cardioprotective Effect of Carvedilol against Hypoxia/Reoxygenation Injury in Cultured Rat Cardiac Myocytes
• -343-PREPARATION AND APPLICATION OF MONOCLONAL ANTIBODIES AGAINST ATRIAL NATRIURETIC POLYPEPTIDE (ANP) : HIGHLY SENSITIVE SANDWICH ENZYME IMMUNOASSAYS FOR α-, β- AND γ-ANP : Atrial Natriuretic Polypeptide : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53t
• Central Actions of Atrial Natriuretic Polypeptides in Spontaneously Hypertensive and Normotensive rats
• -416- EFFECTS OF BAY K 8644, A VOLTAGE-SENSITIVE CALCIUM CHANNEL AGONIST, ON SECRETION OF ATRIAL NATRIURETIC POLYPEPTIDE FROM ISOLATED RAT HEARTS
• PLASMA CONCENTRATIONS OF ATRIAL NATRIURETIC POLYPEPTIDE IN HUMAN CARDIOVASCULAR DISORDERS : Atrial Natriuretic Polypeptide (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• RELATIONSHIP BETWEEN SECRETION OF ATRIAL NATRIURETIC POLYPEPTIDE AND HEMODYNAMICS IN MAN : Atrial Natriuretic Polypeptide (I) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EXERCISE INDUCES SECRETION OF ATRIAL NATRIURETIC POLYPEPTIDE FROM THE HEART : Atrial Natriuretic Polypeptide (I) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Effect of HDL on Apoptosis in Human Vascular Endothelial Cells via Caveolin and Heat Shock Protein 90 Dependent Pathway
• Effect of Quinapril on Apoptosis in Human Vascular Endothelial Cells via Bradykinin, Heat Shock Protein 90 and NOX Dependent Pathway
• Effect of Endothelin-3 on Apoptosis via Caveolin and Heat Shock Protein 90 Dependent Pathway in Human Vascular Endothelial Cells
• Effect of HDL on apoptosis in human vascular endothelial cells via caveolin and heat shock protein 90 dependent pathway
• Reverse redistribution of Tc-99m-tetrofosmin in patients with acute myocardial infarction
• COMPARISON BETWEEN ELECTROCARDIOGRAPHIC CHANGES AND THALLIUM-201 MYOCARDIAL PERFUSION IMAGES DURING TRANSIENT CORONARY OCCLUSION BY PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY : RI : 53 Annual Scientific Meeting, Japanese Circulation Society
• IS028 Cyclin A Mediated p53-Independent Apoptosis in Cardiomyocytes Under Hypoxic Conditions
• Retroperitoneal bronchogenic cyst: Report of a case and literature review
• Effect of exercise-induced activation of sympathetic nerve activity on clearance of ^I-MIBG from the myocardium
• RELATIONSHIP AMONG ABNORMALITIES OF THE ULTRASONIC THREE-LAYERED APPEARANCE OF THE VENTRICULAR SEPTUM, MYOCARDIAL FATTY ACID METABOLISM AND PERFUSION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
• THE EVALUATION OF REGIONAL MYOCARDIAL BLOOD FLOW OF THE SEPTAL WALL IN PATIENTS WITH COMPLETE LEFT BUNDLE BRANCH BLOCK
• Improved Survival of Idiopathic Dilated Cardiomyopathy in the 1990s
• MECHANISM OF CIRCULATORY COLLAPSE IN RATS WITH SPONTANEOUSLYOCCURING HYPERTRORHIC CARDIOMYOPATHY
• Aeromonas sobria infection with severe soft tissue damage and segmental necrotizing gastroenteritis in a patient with alcoholic liver cirrhosis
• Chronic Angiotensin Blockade with Candesartan Cilexetil in DOCA/Salt Hypertensive Rats Reduces Cardiac Hypertrophy and Coronary Resistance without Affecting Blood Pressure
• -1120- ROLE OF NITRIC OXIDE IN IMPAIRED CORONARY CIRCULATION AND IMPROVEMENT BY ANGIOTENSIN RECEPTOR ANTAGONIST IN HYPERTENSIVE HEART(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -1045- The Role of Impaired Glucose Tolerance and Hyperinsulinemia on the Development of Hypertension in Sucrose-fed SHR(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Low Frequency Regular Exercise Improves Flow-Mediated Dilatation of Subjects with Mild Hypertension
• Lowering of Blood Pressure Improves Endothelial Dysfunction by Increase of Nitric Oxide Produciton in Hypertensive Rats
• Role of the Central Nervous System in the Development of Hypertension Produced by Chronic Nitric Oxide Blockade in Rats
• P342 ROLE OF NITRIC OXIDE AND EFFECT OF L-ARGININE IN IMPAIRED CORONARY CIRCULATION OF HYPERTENSIVE HEART
• ROLE OF SYMPATHETIC NERVE INHIBITION IN THE VASODEPRESSOR EFFECT OF BROMOCRIPTINE IN NORMOTENSIVE AND HYPERTENSIVE RATS
• CENTRAL DEPRESSOR MECHANISMS OF CALCIUM IN NORMOTENSIVE AND HYPERTENSIVE RATST : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• CENTRAL BAROREFLEX REGULATION BY THE RENAL NERVES IN ANESTHETIZED RATS
• Assessment of Vascular Damage by Pulse Wave Velocity and Photoplethysmogram in Hypertensive Subjects
• Effects of Angiotensin II Type 1 Receptor Antagonist on Pressor Responses to Pulsatile Compression of the Rostral Ventrolateral Medulla in Rats
• Increased Blood Pressure, Drinking, and Salt Preference by Neuron-Specific Expression of Human Renin
• -331-EXPRESSION OF BRAIN NATRIURETIC PEPTIDE (BNP)-ENE IN HEART : Atrial Natriuretic Polypeptide : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -330-BRAIN NATRIURETIC POLYPEPTIDE (BNP) AS A NOVEL CARDIAC HORMONE : Atrial Natriuretic Polypeptide : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Effects of Pravastatin on Exercise Electrocardiography Test Performance and Cardiovascular Mortality and Morbidity in Patients With Hypercholesterolemia : Lipid Intervention Study in Kyoto
• Emerging multifunctional aspects of cellular serine proteinase inhibitors in tumor progression and tissue regeneration
• Solitary fibroleiomyomatous hamartoma of the lung in a patient without a pre-existing smooth-muscle tumor
• Solitary fibrous tumor of the spinal nerve rootlet : Case report and literature survey
• Augmentation of Pulse Wave Velocity Precedes Vascular Structural Changes of the Aorta in Rats Treated with N^ω-Nitro-L-Arginine Methyl Ester
• OJ-110 The Efficacy of Educational Admission Program for Chronic Kidney Disease(Kidney/Renal circulation-1 (H) OJ19,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Contrasting Effects of Angiotensin Type 1 and 2 Receptors on Nitric Oxide Release under Pressure
• Effects of AT1 antagonist on pressor responses to pulsatile compression of the rostral ventrolateral medulla
• Adenoid glioblastoma arising in a patient with neurofibromatosis type-1
• Paradoxically enhanced immunoreactivity of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in cancer cells at the invasion front
• Ovarian teratoma showing a predominant hemangiomatous element with stromal luteinization : Report of a case and review of the literature
• Multiple hepatic peribiliary cysts with cirrhosis
• Ovarian pregnancy : Report of four cases and review of the literature
• 1079 THE ROLE OF HYPOTHALAMIC NITRIC OXIDE IN THE CARDIO-VASCULAR CONTROL DURING SHAKER STRESS IN AWARE RATS.
• OJ-013 HMG-CoA Reductase Inhibitors Upregulate Anti-aging Klotho mRNA via RhoA Inactivation(Neurohumoral Factors 1 (H) : OJ2)(Oral Presentation (Japanese))
• -1155-CO-EXISTENCE OF A FAMILY OF NATRIURETIC PEPTIDES, ANP AND BNP, IN RAT HEART : IMMUNOHISTOCHEMICAL STUDY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0491-HETEROGENEITY AND TISSUE SPECIFICITIES OF RECEPTORS FOR NATRIURETIC PEPTIDES (AND・BNP)
• -344-DEVELOPMENT OP MONOCLONAL ANTIBODIES AGAINST RECEPTORS FOR ATRIAL NATRIURETIC PEPTIDE : Atrial Natriuretic Polypeptide : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Early Detection of Orthostatic Hypotension by Quantitative Sudomotor Axon Reflex Test (QSART) in Type 2 Diabetic Patients
• Roles of hepatocyte growth factor activator (HGFA) and its inhibitor HAI-1 in the regeneration of injured gastrointestinal mucosa
• Atrial natriuretic polypeptide (ANP) in spontanenously hypertensive rats:Evidence for the increased secretion of ANP from the heart
• Altered depressor response to microinjection of adenosine A2 agonist into the nucleus tractus solitarii of SHR
• Role of Nitric Oxide (NO) in Augmented Constrictive Response to Endothelin-1 (ET-1) in Coronary Artery of Hypertensive Heart
• The Role of Brain α2-Adrenergic System in Noradrenergic Projection to Hypothalamus in SHR
• Increased Synthesis and Secretion of Atrial Natriuretic Polypeptide (ANP) in the Left Atrium of Spontaneously Hypertensive Rats (SHR):Simultaneous Measurement of ANP Messenger RNA and ANP
• Clonidine Improves Central Attenuation of the Baroreflex in Spontaneously Hypertensive Rats.
• Effect of Angiotensin II Receptor Antagonist, TCV-116, on Cardiac Hypertrophy and Coronary Circulation in Spontaneously Hypertensive Rats
• Enhanced norepinephrine release in hypothalamus from locus coeruleus in SHR.

もっと見る 閉じる

スポンサーリンク