Clonidine Improves Central Attenuation of the Baroreflex in Spontaneously Hypertensive Rats.
スポンサーリンク
概要
- 論文の詳細を見る
To determine whether clonidine can improve the central alteration of the baroreflex in SHR, the centrally cut end of the aortic depressor nerve was electrically stimulated in SHR with intravenously administered clonidine. Aortic depressor nerve (ADN) stimulation elicited depressor and sympatho-inhibitory responses in a frequency-dependent manner in WKY and SHR. These responses were significantly smaller in SHR than in WKY. The attenuated depressor and sympatho-inhibitory responses to ADN stimulation in SHR were restored following i.v. injections of clonidine, although the drug did not affect the responses to ADN stimulations in WKY. These findings suggest that clonidine can improve central attenuation of the baroreflex in hypertension.
- International Heart Journal刊行会の論文
著者
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Itoh Hiroshi
Second Department Of Medicine Asahikawa Medical College
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Takesako Toshiyuki
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Nakata Tetsuo
Second Department of Medicine, Kyoto Prefectural University of Medicine
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HAYASHI JUNKO
Second Department of Medicine, Kyoto Prefectural University of Medicine
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Hayashi Junko
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Nakata Tetsuo
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Tanabe Shinichi
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Hirata Masahiro
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Sasaki Susumu
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural Medical College
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TAKEDA Kazuo
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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KUWABARA Tadao
Second Department of Medicine, Kyoto Prefectural University of Medicine
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ITOH Hiroshi
Second Department of Medicine, Kyoto Prefectural University of Medicine
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