Acute effects of captopril on the baroreflex of normotensive and spontaneously hypertensive rats.
スポンサーリンク
概要
- 論文の詳細を見る
When captopril was injected intravenously in urethane anesthetized rats, a hypotensive effect accompanied by bradycardia was obtained, while an intravenous (i. v.) injection of prostaglandin I2 (PGI2), which induced hypotension of the same magnitude as the hypotensive effect obtained with captopril, caused a marked tachycardia. Simultaneously, sympathetic nerve activity recorded from abdominal sympathetic nerves was unchanged following injection of captopril, while it was significantly increased during hypotension induced by PGI2. The bradycardia, but not the hypotensive effects induced by captopril was abolished by i. v. pretreatment with atropine. Intracisternal injection of a small dose of captopril inhibited reflex tachycardia during hypotension induced by PGI2 and prolonged the hypotensive effect, while intravenous administration of this dose did not inhibit the reflex tachycardia induced by PGI2. In spontaneously hypertensive rats (SHR), the hypotensive effect of captopril was increased partly, however, the accompanying bradycardia was significantly reduced. These findings suggest that captopril inhibits the baroreflex and centrally activates the cardiac vagal nerve. Moreover in SHR, the effect of captopril on cardiac vagal activity was disturbed.
- International Heart Journal刊行会の論文
著者
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NAKAMURA Yutaka
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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FUKUYAMA Masaki
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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INOUE Atsushi
Second Department of Internal Medicine. Kyoto Prefectural University of Medicine
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OGURO MINAKO
Second Department of Medicine, Kyoto Prefectural University of Medicine
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Oguro Minako
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Sasaki Susumu
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Ijichi Hamao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural Medical College
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YOSHIMURA MANABU
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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TAKEDA Kazuo
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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ASHIZAWA Hiroshi
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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FUKUYAMA Masaki
Second Department of Medicine, Kyoto Prefectural University of Medicine
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Yoshimura Manabu
Second Department of Medicine, Kyoto Prefectural University of Medicine
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LEE Lee-Chik
Second Department of Medicine, Kyoto Prefectural University of Medicine
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