Measurement of serum thyroxine binding prealbumin in various thyroidal states by radioimmunoassay.
スポンサーリンク
概要
- 論文の詳細を見る
Serum thyroxine binding prealbumin (TBPA) levels in various thyroidal states were examined by radioimmunoassay (RIA). This technique is highly sensitive, accurate and reproducible. The normal mean (±2SD) level of serum TBPA is 26.9±8.0 mg/dl (29.4±5.2 in men and 24.9±7.6 mg/dl in women). Serum TBPA levels in pregnant women were significantly lower than in normal females (P<0.05). Serum TBPA levels in patients with untreated hyperthyroidism were 12.9±4.0 mg/dl (mean±SD) and in patients with untreated hypothyroidism were 25.2±4.7 mg/dl (mean±SD). The mean TBPA concentrations in untreated hyperthyroidism were significantly lower than that for normal population (P<0.01), but untreated hypothyroidism was almost within normal range. The changes in TBPA levels in hyperthyroidism and hypothyroidism were similar to those in TBG levels. In untreated hyper-and hypothyroidism, restoration to euthyroidism by treatment was uniformly accompanied by a normalization of serum TBPA and TBG levels.<BR>A negative correlation between serum thyroid hormone binding protein (TBG and TBPA) and free thyroxine was observed in patients with hyperthyroidism. The coefficient of correlation between TBPA and free thyroxine was -0.80 (P<0.01) and between TBG and free thyroxine -0.58 (P<0.01).<BR>From these experiments it appears that not only TBG but also TBPA may play an important role in the regulation of the free thyro xine concentration in response to various thyroidal states.
- 社団法人 日本内分泌学会の論文
著者
-
HACHIYA TAKASHI
Second Department of Surgery, Hamamatsu University School of Medicine
-
MIYAZAKI TADAYOSHI
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
-
OCHI YUKIO
Second Department of Internal Medicine Shiga University of Medical Science
-
ISHIDA MASAO
Department of Internal Medicine Nantan General Hospital
-
Kajita Yoshihiro
Department Of Internal Medicine Nantan Hospital
-
Ijichi Hamao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
-
OCHI YUKIO
Second Department of Internal Medicine, Shiga University of Medical Science
-
YOSHIMURA MANABU
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
-
HACHIYA Takashi
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
-
ISHIDA MASAO
Department of lnternal Medicine, Nantan General Hospital
-
KAJITA YOSHIHIRO
Department of Internal Medicine Nantan General Hospital
-
KAJITA YOSHIHIRO
Department of lnternal Medicine, Nantan General Hospital
関連論文
- DNA Cytofluorometry of Leukemic Cells identified by Wright-Giemsa Stain; Study on Destaining Method
- Hypotension and Hypothalamic Depression Produced by Intracerebroventricular Injections of GABA in Spontaneously Hypertensive Rats : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Renal Denervation Inhibits Hypothalamo-Sympathetic Nerve System in Normotensive and Hypertensive Rats : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Quinine-resistant Severe Falciparum Malaria Effectively Treated with Atovaquone and Proguanil Hydrochloride Combination Therapy
- CENTRALLY INHIBITORY EFFECT OF ADRENALLINE ON CARDIOVASCULAR AND SYMPATHETIC NERVE SYSTEM IN URETHANE ANESTHETIZED RAT
- The Role of Prostaglandins in the Regulation of Blood Pressure with Special Reference to Vascular Reactivity : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES
- CENTRALLY-INDUCED VASOPRESSOR RESPONSES TO OUABAIN ARE AUGMENTED IN SPONTANEOUSLY HYPERTENSIVE RATS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
- HETEROGENEITY OF VASODEPRESSOR RESPONSES BY CAPTOPRIL : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- Thyroid Stimulating Immunoglobulin (TSI) in Graves' Disease
- -105- HIGH FIBRINOPEPTIDE A (FPA) LEVELS IN ATRIAL FIBRILLATION AND THE EFFECTS OF HEPARIN ADMINISTRATION : Pulmonary Circulation, Papillary Circulation : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATI
- IMPLICATION OF Na^+,Ca^ OR Na^+-K^+ ATPase ON PGI_2 GENERATION IN CULTURED HUMAN VASCULAR ENDOTHELIAL CELLS : Pathophysiology, Vessel : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PROSTACYCLIN GENERATION BY CULTURED HUMAN VASCULAR ENDOTHELIAL CELLS WITH REFERENCE TO ANGIOTENSIN I-CONVERTING ENZYME
- Primary Dissection of the Hepatic Artery : Report of a Case
- The Role of Brain Angiotensin II in the Mechanism of the Pressor Responses to Intracisternal Injection of Hypertonic NaCl in Urethane Anesthetized Rats : THE 11th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Effect of Sodium Loading and Depletion on Vascular Reactivity and Prostacyclin Generation : IX Conference on the Pathogenesis of Hypertension
- The Origin and Clinical Significance of Thyroid Murmur
- STUDIES ON β-PYRIDYLCARBINOL AS A PRECURSOR OF NICOTINAMIDE ADENINE DINUCLEOTIDE
- Enhanced Vascular Reactivity to Norepinephrine in Salt-Sensitive Patients with Hypertension
- Familial Dysalbuminemic Hypertriiodothyroninemia in a Japanese Kindred
- An Assay for Antibodies to Thyroid Plasma Membrane Using the Isotope-labeled Protein A
- Clinical Study on Increased Serum Thyroxine-Binding Globulin in Cancerous State
- Urinary Excretion of LATS in a Patient with Gravesdisease Complicated by Nephrotic Syndrome
- Effect of Biogenic Amines on TRH-TSH System
- An Attempt to Analyze Various Thyroid Stimulators by the Receptor Assay using hTSH Radioimmunoassay
- Changes in the Cyclic Nucleotides of Rat Thyroid, Pituitary and Plasma Caused by Methylthiouracil Treatment
- Effect of LATS, TSH and Cholera Toxin on the Thyroid Gland in Nude Mice
- Determination of Triiodothyronine in Red Blood Cells by Radioimmunoassay
- Immunological Studies on LATE-immunoglobulin by the Reaction with Staphylococcal Protein A
- Radioimmunoassay for Estimation of Thyroglobulin in Human Serum
- Stimulation of Pitutitary Glucose-6-Phosphate Dehydrogenase Activity in the Rat Associated with Increased TSH Secretion
- Dextran-Coated Charcoal Technique to Make the Hormone-Free Serum as a Diluent for Standard Curve of Radioimmunoassay
- The Role of Hypothalamo-sympathetic Nerve System to Maintain High Blood Pressure in DOCA Hypertensive Rats : IX Conference on the Pathogenesis of Hypertension
- Effect of sodium loading and depletion on cyclic nucleotides in plasma and aorta. Interaction between prostacyclin and cyclic nucleotides.
- The Study of the Third Heart Sound in Relation to the Left Ventricular Filling and Wall Movement by Echocardiography
- Effect of prostaglandin E1 on renin and aldosterone in hypertensive patients.
- Serum T3 Level in the Patients with Hyperthyroidism After Therapy
- Measurement of serum thyroxine binding prealbumin in various thyroidal states by radioimmunoassay.
- Left ventricular size and performance during graded supine exercise in normal subjects.
- Lack of active site for Kyotorphin in rat mast cells: Assessment by its effect on IgE-mediated 14C-serotonin release.
- Comparative study of two methods of estimating sinoatrial conduction time in patients with abnormal sinus node function.
- Simultaneous changes of left ventricular and left atrial size and function in normal subjects during exercise.
- Enhanced Pressor Responses to Intracisternal Injection of Hypertonic Saline and It's Brain mechanisms in urethane Anesthetized SHR
- Effects of S-596, a new beta-adrenoceptor blocking agent on the left ventricular performance of normal subjects during exercise.
- The Effect of Propranolol on Blood Pressure and Sympathetic Nerve Activity in the Spontaneously Hypertensive Rats
- Acute effects of captopril on the baroreflex of normotensive and spontaneously hypertensive rats.
- Vasodepressor effects of prazosin during insulin-induced hypoglycemia in hypertensive patients.
- Role of prostaglandins in naturiuresis of perfused kidney in SHR
- Augmented central cholinergic mechanisms in spontaneously hypertensive rats. Involvement of deranged noradrenergic mechanisms in the brain.:Involvement of Deranged Noradrenergic Mechanisms in the Brain