Augmented central cholinergic mechanisms in spontaneously hypertensive rats. Involvement of deranged noradrenergic mechanisms in the brain.:Involvement of Deranged Noradrenergic Mechanisms in the Brain

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概要

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• Intracerebroventricular (ICV) injections of carbachol produced biphasic blood pressure responses consisting of initial vasodepression of short duration followed by a sustained pressor phase, which were accompanied by corresponding changes in sympathetic nerve activity in normotensive outbred-Wistar rats (NT) under urethaneanesthesia. In both normotensive Kyoto Wistar rats (WKY) and spontaneously hypertensive rats (SHR), on the other hand, carbachol elicited purely pressor responses, and accompanying sympathetic nerve activity was little affected. The magnitude of the pressor responses was larger in SHR than in WKY or NT rats. Spinal sectioning did not affect the magnitude of the pressor responses. Vasopressor responses to intravenous injections of arginine-vasopressin were not significantly different between WKY and SHR.These results indicate that carbachol injected intracerebroventricularly produces vasopressor effects mainly by releasing pituitary hormones, probably vasopressin, and that augmented pressor responses in SHR may be due to excessive release of vasopressin.When central noradrenergic neurons had been destroyed with ICV injections of 6-hydroxydopamine in both NT and WKY rats, carbachol-induced vasopressor responses were markedly augmented and resulted in responses similar to those of SHR. These findings indicate that central noradrenergic vasodepressive neurons are deficient and that the augmented vasopressor responses to carbachol resulted from deranged central noradrenergic mechanisms in SHR.

• International Heart Journal刊行会の論文

著者

• INOUE Atsushi

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• OKAJIMA HIROSHI

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• Sasaki Susumu

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Ijichi Hamao

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural Medical College

• YOSHIMURA MANABU

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• TAKAHASHI Hakuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Okajima Hiroshi

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

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